In vivo quantitative tissue characterization of human coronary arterial plaques by use of integrated backscatter intravascular ultrasound and comparison with …

…, M Arai, K Nishigaki, G Takemura, S Minatoguchi… - Circulation, 2002 - Am Heart Assoc
Background— The purpose of the present study was to define whether integrated
backscatter (IB) combined with conventional intravascular ultrasound (IVUS) makes tissue …

Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair

…, T Noda, T Fujiwara, K Fukuda, S Minatoguchi… - Circulation, 1999 - Am Heart Assoc
Background—The presence of apoptotic myocytes has been reported in human hearts with
dilated cardiomyopathy (DCM) on the basis of a positive finding of DNA in situ nick end-…

Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by …

S Minatoguchi, G Takemura, XH Chen, N Wang… - Circulation, 2004 - Am Heart Assoc
Background— We investigated whether the improvement of cardiac function and remodeling
after myocardial infarction (MI) by granulocyte colony–stimulating factor (G-CSF) relates to …

Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three-dimensional integrated backscatter intravascular …

…, Y Ito, I Murata, K Tsuchiya, S Minatoguchi… - Journal of the American …, 2005 - jacc.org
Objectives : The purpose of the present study was twofold: 1) to evaluate the usefulness of
three-dimensional (3D) integrated backscatter (IB) intravascular ultrasound (IVUS) for …

Process of progression of coronary artery lesions from mild or moderate stenosis to moderate or severe stenosis: a study based on four serial coronary arteriograms …

…, K Nishigaki, G Takemura, T Noda, S Minatoguchi… - Circulation, 1999 - Am Heart Assoc
Background—The process of progression in coronary artery disease is unknown. Methods
and Results—The subjects were 36 patients with 36 objective vessels with clinically …

Postinfarction gene therapy against transforming growth factor-β signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure

…, S Miyata, R Maruyama, A Mikami, S Minatoguchi… - Circulation, 2005 - Am Heart Assoc
Background— Fibrosis and progressive failure are prominent pathophysiological features of
hearts after myocardial infarction (MI). We examined the effects of inhibiting transforming …

Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion

…, M Seishima, S Minatoguchi - American Journal …, 2011 - journals.physiology.org
Ischemia is known to potently stimulate autophagy in the heart, which may contribute to
cardiomyocyte survival. In vitro, transfection with small interfering RNAs targeting Atg5 or Lamp-2 …

Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes

…, H Okada, M Kawasaki, M Seishima, S Minatoguchi - Autophagy, 2015 - Taylor & Francis
Little is known about the association between autophagy and diabetic cardiomyopathy. Also
unknown are possible distinguishing features of cardiac autophagy in type 1 and type 2 …

The role of autophagy emerging in postinfarction cardiac remodelling

…, H Fujiwara, M Seishima, S Minatoguchi - Cardiovascular …, 2011 - academic.oup.com
Aims Autophagy is activated in cardiomyocytes in ischaemic heart disease, but its dynamics
and functional roles remain unclear after myocardial infarction. We observed the dynamics …

“Apoptotic” myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: analysis by immunogold electron microscopy combined with in …

…, A Ohno, J Misao, Y Hayakawa, S Minatoguchi… - Circulation, 1998 - Am Heart Assoc
Background—Modes of cell death have been defined morphologically as apoptosis and
oncosis. Infarcted myocytes have been reported to show apoptosis, as revealed by DNA …