[PDF][PDF] Virological characteristics of the SARS-CoV-2 Omicron BA. 2 spike

…, R Fujiki, A Kaneda, T Shimada, T Nakada, S Sakao… - Cell, 2022 - cell.com
Soon after the emergence and global spread of the SARS-CoV-2 Omicron lineage BA.1,
another Omicron lineage, BA.2, began outcompeting BA.1. The results of statistical analysis …

Initial apoptosis is followed by increased proliferation of apoptosis‐resistant endothelial cells

S Sakao, L Taraseviciene‐Stewart, JD Lee… - The FASEB …, 2005 - Wiley Online Library
We have demonstrated that VEGF receptor blockade in combination with chronic hypoxia
causes in rats severe angioproliferative pulmonary hypertension (SAPH) associated with …

[HTML][HTML] Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation

S Sakao, K Tatsumi, NF Voelkel - Respiratory research, 2009 - Springer
Severe pulmonary arterial hypertension, whether idiopathic or secondary, is characterized by
structural alterations of microscopically small pulmonary arterioles. The vascular lesions in …

Virological characteristics of SARS-CoV-2 BA. 2 variant

…, R Fujiki, A Kaneda, T Shimada, T Nakada, S Sakao… - BioRxiv, 2022 - biorxiv.org
Soon after the emergence and global spread of a new severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) Omicron lineage, BA.1 (ref 1 , 2 ), another Omicron lineage, BA.2…

Association of tumor necrosis factor α gene promoter polymorphism with the presence of chronic obstructive pulmonary disease

S Sakao, K Tatsumi, H Igari, Y Shino… - American journal of …, 2001 - atsjournals.org
Tumor necrosis factor α (TNF- α ), a potent proinflammatory cytokine, may be involved in the
development of chronic obstructive pulmonary disease (COPD). The production of TNF- α is …

Reversible or irreversible remodeling in pulmonary arterial hypertension

S Sakao, K Tatsumi, NF Voelkel - American journal of respiratory …, 2010 - atsjournals.org
Vascular remodeling is an important pathological feature of pulmonary arterial hypertension
(PAH), which leads to increased pulmonary vascular resistance, with marked proliferation of …

The vascular bed in COPD: pulmonary hypertension and pulmonary vascular alterations

S Sakao, NF Voelkel, K Tatsumi - European respiratory review, 2014 - Eur Respiratory Soc
The loss of pulmonary vessels has been shown to be related to the severity of pulmonary
hypertension in patients with chronic obstructive pulmonary disease (COPD). The severity of …

Vascular remodeling in pulmonary arterial hypertension: multiple cancer-like pathways and possible treatment modalities

S Sakao, K Tatsumi - International journal of cardiology, 2011 - Elsevier
Most patients with severe pulmonary arterial hypertension (PAH) at the time of diagnosis
tend to demonstrate persistent structural alterations in their microscopically small pulmonary …

Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis

…, Y Takiguchi, O Okada, N Yumoto, S Sakao… - The Journal of …, 2008 - journals.aai.org
Consistent with the hypothesis that pulmonary epithelial apoptosis is the key to the acute
exacerbation of idiopathic pulmonary fibrosis (IPF), we conducted serological identification of …

Role of 320-slice CT imaging in the diagnostic workup of patients with chronic thromboembolic pulmonary hypertension

…, A Shigeta, N Kawata, T Jujo, N Yanagawa, S Sakao… - Chest, 2013 - Elsevier
Seiichiro Sakao MD, PhD , Yasunori Kasahara MD, PhD, FCCP , Koichiro Tatsumi MD, PhD,
FCCP … Dr Sakao: contributed to the RHC and invasive PDSA study and critical review of the …