We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic
idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up …

Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease that probably
involves several genetic loci. Several rare genetic variants and one common single nucleotide …

Importance Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF),
which are based on clinical and physiological parameters, have modest value in predicting …

Future treatments for chronic hepatitis C virus (HCV) infection are likely to include agents
that target viral components directly. Here, the preclinical characteristics of ITMN-191, a …

Deletion of uridylates from the 3′-most editing site of synthetic ATPase 6 pre-mRNA can be
visualized directly by coincubation of a radiolabeled substrate RNA and a synthetic gRNA in …

In the mitochondria of trypanosomatid protozoa the precursors of messenger RNAs (pre-mRNAs)
have their coding information remodeled by the site-specific insertion and deletion of …

HCV serine protease NS3 represents an attractive drug target because it is not only essential
for viral replication but also implicated in the viral evasion of the host immune response …

Mitochondrial transcripts in kinetoplastids undergo remarkable posttranscriptional editing by
uridylate insertion and deletion. The often dramatic remodeling of pre-mRNA sequences is …

RNA editing in the mitochondrion of Trypanosoma brucei extensively alters the adenosine
triphosphate synthase (ATPase) subunit 6 precursor messenger RNA (pre-mRNA) by addition …

Background Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases
with largely unknown etiology and without definitive treatment other than lung transplant to …