The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …

The spike aspartic acid–614 to glycine (D614G) substitution is prevalent in global severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral …

The pseudostratified epithelium of the mouse trachea and human airways contains a population
of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5) and Krt14. Using a KRT5…

Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type
1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. …

The pathogenesis of cystic fibrosis (CF) airways infection is unknown. Two hypotheses, "hypotonic
[low salt]/defensin" and "isotonic volume transport/mucus clearance," attempt to link …

Current theories of CF pathogenesis predict different predisposing “local environmental”
conditions and sites of bacterial infection within CF airways. Here we show that, in CF patients …

The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle
East respiratory syndrome (MERS)-CoV underscores the threat of cross-species …

Respiratory disease is the third leading cause of death in the industrialized world. Consequently,
the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive …

The small airways of the human lung undergo pathological changes in pulmonary disorders,
such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans …

The airway epithelium occupies a critical environmental interface, protecting the host from a
wide variety of inhaled insults, including chemical and particulate pollutants and pathogens. …