During mouse lung morphogenesis, the distal mesenchyme regulates the growth and
branching of adjacent endoderm. We report here that fibroblast growth factor 10 (Fgf10) is …

Epithelial-mesenchymal interactions are critical for the branching and differentiation of the
lung, but the mechanisms involved are still unclear. To investigate this problem in mouse …

Branching morphogenesis of the embryonic lung requires interactions between the epithelium
and the mesenchyme. Previously, we reported that Sonic hedgehog (Shh) transcripts are …

The Drosophila (fruit fly) model system has been instrumental in our current understanding
of human biology, development, and diseases. Here, we used a high-throughput yeast two-…

The importance of mesenchymal-epithelial interactions for the proper development of the
pancreas has been acknowledged since the early 1960s, even though the molecule(s) …

Developmental lung biology is a field that has the potential for significant human impact: lung
disease at the extremes of age continues to cause major morbidity and mortality worldwide…

In the mature mouse lung, the proximal-distal (PD) axis is delineated by two distinct epithelial
subpopulations: the proximal bronchiolar epithelium and the distal respiratory epithelium. …

Fibrosis is associated with organ failure and high mortality and is commonly characterized
by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in …

A new source of stem cells has recently been isolated from amniotic fluid; these amniotic fluid
stem cells have significant potential for regenerative medicine. These cells are multipotent, …

The mouse develops five pairs of mammary glands that arise during mid-gestation from five
pairs of placodes of ectodermal origin. We have investigated the molecular mechanisms of …