Prostaglandin E2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cyclic AMP in human macrophages
…, HY Qi, C Logun, S Alsaaty… - The Journal of …, 2015 - journals.aai.org
PGE 2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of
acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-…
acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-…
The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A2 via GPR120 receptor to produce prostaglandin E2 and plays an anti …
…, LY Chen, M Sokolowska, M Eberlein, S Alsaaty… - …, 2014 - Wiley Online Library
Docosahexaenoic acid (DHA) is one of the major ingredients of fish oil and has been reported
to have anti‐inflammatory properties mediated through the GPR120 receptor. Whether …
to have anti‐inflammatory properties mediated through the GPR120 receptor. Whether …
[HTML][HTML] Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages*♦
…, M Eberlein, A Martinez-Anton, Y Liu, S Alsaaty… - Journal of Biological …, 2014 - ASBMB
Hyaluronan (HA) is the major glycosaminoglycan in the extracellular matrix. During inflammation,
there is an increased breakdown of HA, resulting in the accumulation of low molecular …
there is an increased breakdown of HA, resulting in the accumulation of low molecular …
Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma
…, Y Liu, A Martinez-Anton, C Logun, S Alsaaty… - Journal of Allergy and …, 2017 - jacionline.org
1. Gascon M, Casas M, Morales E, Valvi D, Ballesteros-Gomez A, Luque N, et al. Prenatal
exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. …
exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. …
Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells
We studied the changes in expression of microRNAs (miRNAs or miRs) and mRNA in normal
human bronchial epithelial cells as they differentiate from an undifferentiated monolayer to …
human bronchial epithelial cells as they differentiate from an undifferentiated monolayer to …
Concentration-dependent noncysteinyl leukotriene type 1 receptor-mediated inhibitory activity of leukotriene receptor antagonists
G Woszczek, LY Chen, S Alsaaty… - The journal of …, 2010 - journals.aai.org
The use of cysteinyl leukotriene receptor antagonists (LTRAs) for asthma therapy has been
associated with a significant degree of interpatient variability in response to treatment. Some …
associated with a significant degree of interpatient variability in response to treatment. Some …
A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages
…, MP Daniels, Y Liu, LY Chen, S Alsaaty… - The Journal of …, 2011 - journals.aai.org
Autophagy delivers cytoplasmic constituents to autophagosomes and is involved in innate
and adaptive immunity. Cytosolic phospholipase (cPLA 2)-initiated proinflammatory lipid …
and adaptive immunity. Cytosolic phospholipase (cPLA 2)-initiated proinflammatory lipid …
IFN-γ induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes
…, LY Chen, S Nagineni, S Alsaaty… - The Journal of …, 2007 - journals.aai.org
Cysteinyl leukotrienes (cysLTs) are important mediators of cell trafficking and innate immune
responses, involved in the pathogenesis of inflammatory processes, ie, atherosclerosis, …
responses, involved in the pathogenesis of inflammatory processes, ie, atherosclerosis, …
[HTML][HTML] 1918 Influenza receptor binding domain variants bind and replicate in primary human airway cells regardless of receptor specificity
…, L Qi, LM Schwartzman, J Suzich, S Alsaaty… - Virology, 2016 - Elsevier
The 1918 influenza pandemic caused ~50 million deaths. Many questions remain regarding
the origin, pathogenicity, and mechanisms of human adaptation of this virus. Avian-adapted …
the origin, pathogenicity, and mechanisms of human adaptation of this virus. Avian-adapted …
[HTML][HTML] Impact of animal strain on gene expression in a rat model of acute cardiac rejection
…, PC Minneci, H Chen, SJ Kern, C Logun, S Alsaaty… - BMC genomics, 2009 - Springer
Background The expression levels of many genes show wide natural variation among strains
or populations. This study investigated the potential for animal strain-related genotypic …
or populations. This study investigated the potential for animal strain-related genotypic …