Prostaglandin E2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cyclic AMP in human macrophages

…, HY Qi, C Logun, S Alsaaty… - The Journal of …, 2015 - journals.aai.org
PGE 2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of
acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-…

The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A2 via GPR120 receptor to produce prostaglandin E2 and plays an anti …

…, LY Chen, M Sokolowska, M Eberlein, S Alsaaty… - …, 2014 - Wiley Online Library
Docosahexaenoic acid (DHA) is one of the major ingredients of fish oil and has been reported
to have anti‐inflammatory properties mediated through the GPR120 receptor. Whether …

[HTML][HTML] Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages*♦

…, M Eberlein, A Martinez-Anton, Y Liu, S Alsaaty… - Journal of Biological …, 2014 - ASBMB
Hyaluronan (HA) is the major glycosaminoglycan in the extracellular matrix. During inflammation,
there is an increased breakdown of HA, resulting in the accumulation of low molecular …

Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma

…, Y Liu, A Martinez-Anton, C Logun, S Alsaaty… - Journal of Allergy and …, 2017 - jacionline.org
1. Gascon M, Casas M, Morales E, Valvi D, Ballesteros-Gomez A, Luque N, et al. Prenatal
exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy. …

Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells

…, S Kern, AS Davis, S Alsaaty… - American journal of …, 2013 - atsjournals.org
We studied the changes in expression of microRNAs (miRNAs or miRs) and mRNA in normal
human bronchial epithelial cells as they differentiate from an undifferentiated monolayer to …

Concentration-dependent noncysteinyl leukotriene type 1 receptor-mediated inhibitory activity of leukotriene receptor antagonists

G Woszczek, LY Chen, S Alsaaty… - The journal of …, 2010 - journals.aai.org
The use of cysteinyl leukotriene receptor antagonists (LTRAs) for asthma therapy has been
associated with a significant degree of interpatient variability in response to treatment. Some …

A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages

…, MP Daniels, Y Liu, LY Chen, S Alsaaty… - The Journal of …, 2011 - journals.aai.org
Autophagy delivers cytoplasmic constituents to autophagosomes and is involved in innate
and adaptive immunity. Cytosolic phospholipase (cPLA 2)-initiated proinflammatory lipid …

IFN-γ induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes

…, LY Chen, S Nagineni, S Alsaaty… - The Journal of …, 2007 - journals.aai.org
Cysteinyl leukotrienes (cysLTs) are important mediators of cell trafficking and innate immune
responses, involved in the pathogenesis of inflammatory processes, ie, atherosclerosis, …

[HTML][HTML] 1918 Influenza receptor binding domain variants bind and replicate in primary human airway cells regardless of receptor specificity

…, L Qi, LM Schwartzman, J Suzich, S Alsaaty… - Virology, 2016 - Elsevier
The 1918 influenza pandemic caused ~50 million deaths. Many questions remain regarding
the origin, pathogenicity, and mechanisms of human adaptation of this virus. Avian-adapted …

[HTML][HTML] Impact of animal strain on gene expression in a rat model of acute cardiac rejection

…, PC Minneci, H Chen, SJ Kern, C Logun, S Alsaaty… - BMC genomics, 2009 - Springer
Background The expression levels of many genes show wide natural variation among strains
or populations. This study investigated the potential for animal strain-related genotypic …