Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity
…, P Giral, E Nobecourt, S Chantepie… - The Journal of …, 2004 - academic.oup.com
A metabolic syndrome (MetS) phenotype is characterized by insulin-resistance, atherogenic
dyslipidemia, oxidative stress, and elevated cardiovascular risk and frequently involves …
dyslipidemia, oxidative stress, and elevated cardiovascular risk and frequently involves …
Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress
A Kontush, S Chantepie… - … , thrombosis, and vascular …, 2003 - Am Heart Assoc
Objectives— The relationship of the structural and functional heterogeneity of HDL particles
to protection of LDL against oxidative stress is indeterminate. Methods and Results— HDL …
to protection of LDL against oxidative stress is indeterminate. Methods and Results— HDL …
Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function
WS Davidson, RAGD Silva, S Chantepie… - … , and vascular biology, 2009 - Am Heart Assoc
Objective— Recent proteomic studies have identified multiple proteins that coisolate with
human HDL. We hypothesized that distinct clusters of protein components may distinguish …
human HDL. We hypothesized that distinct clusters of protein components may distinguish …
Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and …
…, JA de Souza, S Chantepie… - … , and vascular biology, 2007 - Am Heart Assoc
Objective— The purpose of this study was to define heterogeneity in the molecular profile of
lipids, including sphingomyelin and sphingosine-1-phosphate, among physicochemically-…
lipids, including sphingomyelin and sphingosine-1-phosphate, among physicochemically-…
HDL3-mediated inactivation of LDL-associated phospholipid hydroperoxides is determined by the redox status of apolipoprotein AI and HDL particle surface lipid …
A Zerrad-Saadi, P Therond, S Chantepie… - … , and vascular biology, 2009 - Am Heart Assoc
Objectives— Small dense HDL3 particles of defined lipidome and proteome potently protect
atherogenic LDL against free radical-induced oxidation; the molecular determinants of such …
atherogenic LDL against free radical-induced oxidation; the molecular determinants of such …
Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A‐I
…, M Couturier, P Therond, S Chantepie… - Journal of cellular …, 2010 - Wiley Online Library
Plasma high‐density lipoproteins (HDLs) protect endothelial cells against apoptosis induced
by oxidized low‐density lipoprotein (oxLDL). The specific component(s) of HDLs implicated …
by oxidized low‐density lipoprotein (oxLDL). The specific component(s) of HDLs implicated …
A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity
A Kontush, EC de Faria, S Chantepie, MJ Chapman - Atherosclerosis, 2005 - Elsevier
OBJECTIVE:: Low levels of high density lipoprotein-cholesterol (HDL-C) are highly prevalent
in subjects presenting premature atherosclerosis. It is indeterminate as to whether high …
in subjects presenting premature atherosclerosis. It is indeterminate as to whether high …
Metabolic syndrome features small, apolipoprotein AI-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity
…, P Therond, CV Serrano Jr, S Chantepie… - Atherosclerosis, 2008 - Elsevier
The metabolic syndrome (MetS) phenotype is typically characterized by visceral obesity,
insulin resistance, atherogenic dyslipidemia involving hypertriglyceridemia and subnormal …
insulin resistance, atherogenic dyslipidemia involving hypertriglyceridemia and subnormal …
Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep
Ischemic heart disease is a leading cause of mortality due to irreversible damage to cardiac
muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix (…
muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix (…
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology
…, MB Huynh, MO Ouidja, C Yanicostas, S Chantepie… - Brain, 2015 - academic.oup.com
Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2)
is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated …
is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated …