The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
S Bonnet, G Rochefort, G Sutendra… - Proceedings of the …, 2007 - National Acad Sciences
In pulmonary arterial hypertension (PAH), antiapoptotic, proliferative, and inflammatory
diatheses converge to create an obstructive vasculopathy. A selective down-regulation of the Kv …
diatheses converge to create an obstructive vasculopathy. A selective down-regulation of the Kv …
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived …
H Kajimoto, K Hashimoto, SN Bonnet, A Haromy… - Circulation, 2007 - Am Heart Assoc
Background— Constriction of the ductus arteriosus (DA) is initiated at birth by inhibition of O
2 -sensitive K + channels in DA smooth muscle cells. Subsequent membrane depolarization …
2 -sensitive K + channels in DA smooth muscle cells. Subsequent membrane depolarization …
Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH
…, SN Bonnet, S Provencher, S Bonnet - European …, 2012 - Eur Respiratory Soc
Like cancer, pulmonary arterial hypertension (PAH) is characterised by a pro-proliferative
and anti-apoptotic phenotype. In PAH, pulmonary artery smooth muscle cell (PASMC) …
and anti-apoptotic phenotype. In PAH, pulmonary artery smooth muscle cell (PASMC) …
NFAT activation in pulmonary arterial hypertension; a missing link in the ionic (K+ channel downregulation), inflammatory (T-cell activation) remodeling and a novel …
S Bonnet, G Rochefort, SL Archer, SN Bonnet… - 2006 - Am Heart Assoc
Pulmonary Arterial Hypertension (PAH) is characterized by an apoptosis-resistant,
proliferative and inflammatory vascular remodeling; it is also associated with a selective down-…
proliferative and inflammatory vascular remodeling; it is also associated with a selective down-…
Genetic diversity, transmission and understanding of seed-borne viruses and phytoplasma
Seed-borne plant viruses and phytoplasma are the major constraints in reducing the yield of
many agricultural and horticultural crops worldwide. In this chapter, we have discussed …
many agricultural and horticultural crops worldwide. In this chapter, we have discussed …
[HTML][HTML] First expert elicitation of knowledge on possible drivers of observed increasing human cases of tick-borne encephalitis in Europe
Tick-borne encephalitis (TBE) is a viral disease endemic in Eurasia. The virus is mainly
transmitted to humans via ticks and occasionally via the consumption of unpasteurized milk …
transmitted to humans via ticks and occasionally via the consumption of unpasteurized milk …
[HTML][HTML] Classification of 101 BRCA1 and BRCA2 variants of uncertain significance by cosegregation study: A powerful approach
…, V Bonadona, F Bonnet, MN Bonnet-Dupeyron… - The American Journal of …, 2021 - cell.com
Up to 80% of BRCA1 and BRCA2 genetic variants remain of uncertain clinical significance (VUSs).
Only variants classified as pathogenic or likely pathogenic can guide breast and …
Only variants classified as pathogenic or likely pathogenic can guide breast and …
The C-terminal intact forms of periostin (iPTN) are surrogate markers for osteolytic lesions in experimental breast cancer bone metastasis
E Gineyts, N Bonnet, C Bertholon, M Millet… - Calcified tissue …, 2018 - Springer
Periostin is an extracellular matrix protein that actively contributes to tumor progression and
metastasis. Here, we hypothesized that it could be a marker of bone metastasis formation. To …
metastasis. Here, we hypothesized that it could be a marker of bone metastasis formation. To …
[HTML][HTML] Overview of the genetic causes of hereditary breast and ovarian cancer syndrome in a large French patient cohort
…, S Dussart, C Lasset, S Giraud, MN Bonnet-Dupeyron… - Cancers, 2023 - mdpi.com
Simple Summary Hereditary Breast and Ovarian Cancer syndrome (HBOC) is an inherited
trait that predisposes adults to an earlier onset of cancer than the general population. HBOC …
trait that predisposes adults to an earlier onset of cancer than the general population. HBOC …
[HTML][HTML] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance
and be therapeutically targeted. Compared to normal cells, several human cancers have …
and be therapeutically targeted. Compared to normal cells, several human cancers have …