The outer wall of small airways is a major site of remodeling in fatal asthma
…, BB de Araujo, HAP Gomes, S Fernezlian… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Structural and inflammatory changes in asthma involve both the large and
small airways, with involvement of the distal lung being related to disease severity. We have …
small airways, with involvement of the distal lung being related to disease severity. We have …
Airway proteoglycans are differentially altered in fatal asthma
…, MA dos Santos, S Fernezlian… - The Journal of …, 2005 - Wiley Online Library
It has been suggested that airway remodelling is responsible for the persistent airway
obstruction and decline in lung function observed in some asthmatic patients. The small airways …
obstruction and decline in lung function observed in some asthmatic patients. The small airways …
DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
…, SC Abreu, CS Samary, BL Diaz, S Fernezlian… - Journal of controlled …, 2014 - Elsevier
Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in
experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, …
experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, …
Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic …
DR Waisberg, JV Barbas-Filho, ER Parra, S Fernezlian… - Human pathology, 2010 - Elsevier
Idiopathic pulmonary fibrosis is a distinctive, usually fatal, type of chronic fibrosing interstitial
pneumonia of unknown cause that increases in prevalence with advanced age, …
pneumonia of unknown cause that increases in prevalence with advanced age, …
[HTML][HTML] Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and …
…, C Bueno, MBG Vendramini, SM Fernezlian… - Arthritis research & …, 2019 - Springer
Background Type V collagen (Col V) has the potential to become an autoantigen and has
been associated with the pathogenesis of systemic sclerosis (SSc). We characterized …
been associated with the pathogenesis of systemic sclerosis (SSc). We characterized …
Lymphocytic inflammation in childhood bronchiolitis obliterans
…, J Schrumpf, CE Hack, S Fernezlian… - Pediatric …, 2004 - Wiley Online Library
Childhood bronchiolitis obliterans (CBO) is an infrequent, severe disorder characterized by
persistent obstructive respiratory symptoms after an acute episode of bronchiolitis. The viral …
persistent obstructive respiratory symptoms after an acute episode of bronchiolitis. The viral …
Small airway remodeling in idiopathic interstitial pneumonias: a pathological study
…, R Adib Kairalla, PH Nascimento Saldiva, S Fernezlian… - Respiration, 2010 - karger.com
Background: Few studies have addressed small airway (SA) histopathological changes and
their possible role in the remodeling process in idiopathic interstitial pneumonias. Objectives…
their possible role in the remodeling process in idiopathic interstitial pneumonias. Objectives…
[HTML][HTML] Increased fibroblast telomerase expression precedes myofibroblast α-smooth muscle actin expression in idiopathic pulmonary fibrosis
DR Waisberg, ER Parra, JV Barbas-Filho, S Fernezlian… - Clinics, 2012 - SciELO Brasil
OBJECTIVE: This study sought to identify the relationship between fibroblast telomerase
expression, myofibroblasts, and telomerase-mediated regulatory signals in idiopathic …
expression, myofibroblasts, and telomerase-mediated regulatory signals in idiopathic …
[HTML][HTML] Carcinoid of the minor duodenal papilla associated with pancreas divisum: case report and review of the literature
…, LL Matos, DR Waisberg, HVB Santos, SM Fernezlian… - Clinics, 2006 - SciELO Brasil
Carcinoid tumors of Vater’s ampulla are the most common among the extremely rare primary
ampullary neuroendocrine tumors, accounting for less than 0.35% of all gastrointestinal …
ampullary neuroendocrine tumors, accounting for less than 0.35% of all gastrointestinal …
Bronchoalveolar lavage improves diagnostic accuracy in patients with diffuse lung disease
…, EP Faludi, AB Balthazar, SM Fernezlian… - Diagnostic …, 2013 - Wiley Online Library
Bronchoalveolar lavage (BAL) is an established diagnostic tool in diffuse parenchyma lung
disease. The objective of the present study was designed to investigate whether …
disease. The objective of the present study was designed to investigate whether …