The outer wall of small airways is a major site of remodeling in fatal asthma

…, BB de Araujo, HAP Gomes, S Fernezlian… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Structural and inflammatory changes in asthma involve both the large and
small airways, with involvement of the distal lung being related to disease severity. We have …

Airway proteoglycans are differentially altered in fatal asthma

…, MA dos Santos, S Fernezlian… - The Journal of …, 2005 - Wiley Online Library
It has been suggested that airway remodelling is responsible for the persistent airway
obstruction and decline in lung function observed in some asthmatic patients. The small airways …

DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma

…, SC Abreu, CS Samary, BL Diaz, S Fernezlian… - Journal of controlled …, 2014 - Elsevier
Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in
experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, …

Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic …

DR Waisberg, JV Barbas-Filho, ER Parra, S Fernezlian… - Human pathology, 2010 - Elsevier
Idiopathic pulmonary fibrosis is a distinctive, usually fatal, type of chronic fibrosing interstitial
pneumonia of unknown cause that increases in prevalence with advanced age, …

[HTML][HTML] Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and …

…, C Bueno, MBG Vendramini, SM Fernezlian… - Arthritis research & …, 2019 - Springer
Background Type V collagen (Col V) has the potential to become an autoantigen and has
been associated with the pathogenesis of systemic sclerosis (SSc). We characterized …

Lymphocytic inflammation in childhood bronchiolitis obliterans

…, J Schrumpf, CE Hack, S Fernezlian… - Pediatric …, 2004 - Wiley Online Library
Childhood bronchiolitis obliterans (CBO) is an infrequent, severe disorder characterized by
persistent obstructive respiratory symptoms after an acute episode of bronchiolitis. The viral …

Small airway remodeling in idiopathic interstitial pneumonias: a pathological study

…, R Adib Kairalla, PH Nascimento Saldiva, S Fernezlian… - Respiration, 2010 - karger.com
Background: Few studies have addressed small airway (SA) histopathological changes and
their possible role in the remodeling process in idiopathic interstitial pneumonias. Objectives…

[HTML][HTML] Increased fibroblast telomerase expression precedes myofibroblast α-smooth muscle actin expression in idiopathic pulmonary fibrosis

DR Waisberg, ER Parra, JV Barbas-Filho, S Fernezlian… - Clinics, 2012 - SciELO Brasil
OBJECTIVE: This study sought to identify the relationship between fibroblast telomerase
expression, myofibroblasts, and telomerase-mediated regulatory signals in idiopathic …

[HTML][HTML] Carcinoid of the minor duodenal papilla associated with pancreas divisum: case report and review of the literature

…, LL Matos, DR Waisberg, HVB Santos, SM Fernezlian… - Clinics, 2006 - SciELO Brasil
Carcinoid tumors of Vater’s ampulla are the most common among the extremely rare primary
ampullary neuroendocrine tumors, accounting for less than 0.35% of all gastrointestinal …

Bronchoalveolar lavage improves diagnostic accuracy in patients with diffuse lung disease

…, EP Faludi, AB Balthazar, SM Fernezlian… - Diagnostic …, 2013 - Wiley Online Library
Bronchoalveolar lavage (BAL) is an established diagnostic tool in diffuse parenchyma lung
disease. The objective of the present study was designed to investigate whether …