Conclusions The endothelium is a key organ involved in the pathogenesis of sepsis. Dysfunction
of or injury to the endothelium may be involved in the pathogenesis of multiple organ …

Autoimmune hemolytic anemias (AIHAs) are rare and heterogeneous disorders characterized
by the destruction of red blood cells through warm or cold antibodies. There is currently no …

Disseminated intravascular coagulation is a frequent complication of sepsis. Coagulation
activation, inhibition of fibrinolysis, and consumption of coagulation inhibitors lead to a …

… Zeerleder, Sacha MD; Zwart, Bas MD; Wuillemin, Walter A. MD, PhD; Aarden, Lucien A.
PhD; Groeneveld, AB Johan MD; Caliezi, Christoph MD; van Nieuwenhuijze, Annemarie EM; …

Objective— The formation of neutrophil extracellular traps and the exposure of nucleosomes
on these neutrophil extracellular traps contribute to coagulation activation and the …

In inflammation, extensive cell death may occur, which results in the release of chromatin
components into the extracellular environment. Individually, the purified chromatin components …

Disseminated intravascular coagulation (DIC) is a heterogeneous group of disorders, which
manifest as a spectrum of haemorrhage and thrombosis complicating many primary …

Disruption of the intestinal microbiota occurs frequently in allogeneic hematopoietic cell
transplantation (allo-HCT) recipients and predisposes them to development of graft-versus-host …

C1-inhibitor (C1-inh) is a crucial regulator of the activation of plasmatic cascade systems
involved in inflammation contributing to the homeostasis in the generation of proinflammatory …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …