User profiles for ST Holgate
Stephen HolgateUniversity of Southampton, Faculty of Medicine Verified email at soton.ac.uk Cited by 152236 |
Air pollution and health
B Brunekreef, ST Holgate - The lancet, 2002 - thelancet.com
The health effects of air pollution have been subject to intense study in recent years. Exposure
to pollutants such as airborne participate matter and ozone has been associated with …
to pollutants such as airborne participate matter and ozone has been associated with …
Pathogenesis of asthma
ST Holgate - Clinical & Experimental Allergy, 2008 - Wiley Online Library
While asthma is considered an inflammatory disorder of the conducting airways, it is becoming
increasingly apparent that the disease is heterogeneous with respect to immunopathology…
increasingly apparent that the disease is heterogeneous with respect to immunopathology…
Innate and adaptive immune responses in asthma
ST Holgate - Nature medicine, 2012 - nature.com
The recognition that asthma is primarily an inflammatory disorder of the airways associated
with T helper type 2 (T H 2) cell-dependent promotion of IgE production and recruitment of …
with T helper type 2 (T H 2) cell-dependent promotion of IgE production and recruitment of …
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the …
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the …
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
…, S O'Toole, SH Myint, DAJ Tyrrell, ST Holgate - Bmj, 1995 - bmj.com
Objective: To study the association between upper and lower respiratory viral infections and
acute exacerbations of asthma in schoolchildren in the community. Design: Community …
acute exacerbations of asthma in schoolchildren in the community. Design: Community …
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
Background Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought
to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed …
to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed …
[HTML][HTML] Exposure to House-Dust Mite Allergen (Der p I) and the Development of Asthma in Childhood: A Prospective Study
R Sporik, ST Holgate, TAE Platts-Mills… - New England journal …, 1990 - Mass Medical Soc
Background and Methods. Children with asthma commonly have positive skin tests for
inhaled allergens, and in the United Kingdom the majority of older children with asthma are …
inhaled allergens, and in the United Kingdom the majority of older children with asthma are …
Subepithelial fibrosis in the bronchi of asthmatics
WR Roche, JH Williams, R Beasley, ST Holgate - The Lancet, 1989 - Elsevier
… Beasley R, Roche WR, Roberts JA, Holgate ST Cellular events in the bronchi in mild
asthma and after bronchial provocation. Am Rev Respir Dis (in press). Summary and …
asthma and after bronchial provocation. Am Rev Respir Dis (in press). Summary and …
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
…, S Rorke, JB Clough, JW Holloway, ST Holgate… - Nature, 2002 - nature.com
Asthma is a common respiratory disorder characterized by recurrent episodes of coughing,
wheezing and breathlessness. Although environmental factors such as allergen exposure …
wheezing and breathlessness. Although environmental factors such as allergen exposure …
[HTML][HTML] Mast-cell infiltration of airway smooth muscle in asthma
…, P Bradding, FA Symon, ST Holgate… - … England Journal of …, 2002 - Mass Medical Soc
Background Asthma and eosinophilic bronchitis are characterized by similar inflammatory
infiltrates in the submucosa of the lower airway. However, eosinophilic bronchitis differs from …
infiltrates in the submucosa of the lower airway. However, eosinophilic bronchitis differs from …