User profiles for SE Wenzel

Sally Wenzel

University of Pittsburgh
Verified email at pitt.edu
Cited by 101134

Asthma phenotypes: the evolution from clinical to molecular approaches

SE Wenzel - Nature medicine, 2012 - nature.com
… These results suggest that, despite the relationship between asthma and atopy and allergy,
allergy per se may not be the pathobiological process that initiates asthma, and that other—…

Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome

…, RF Lemanske Jr, AJ Wardlaw, SE Wenzel… - Journal of Allergy and …, 2011 - Elsevier
It is increasingly clear that asthma is a complex disease made up of number of disease
variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of …

Asthma: defining of the persistent adult phenotypes

SE Wenzel - The Lancet, 2006 - thelancet.com
The common disease asthma is probably not a single disease, but rather a complex of
multiple, separate syndromes that overlap. Although clinicians have recognised these different …

Global strategy for asthma management and prevention: GINA executive summary

…, E Pizzichini, SD Sullivan, SE Wenzel… - European …, 2008 - Eur Respiratory Soc
Asthma is a serious health problem throughout the world. During the past two decades, many
scientific advances have improved our understanding of asthma and ability to manage and …

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

KF Chung, SE Wenzel, JL Brozek… - European respiratory …, 2014 - Eur Respiratory Soc
Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

WC Moore, DA Meyers, SE Wenzel… - American journal of …, 2010 - atsjournals.org
Rationale: The Severe Asthma Research Program cohort includes subjects with persistent
asthma who have undergone detailed phenotypic characterization. Previous univariate …

An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials …

…, SJ Szefler, MD Thomas, SE Wenzel - American journal of …, 2009 - atsjournals.org
Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

[HTML][HTML] Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma

EH Bel, SE Wenzel, PJ Thompson… - New England journal …, 2014 - Mass Medical Soc
Background Many patients with severe asthma require regular treatment with oral glucocorticoids
despite the use of high-dose inhaled therapy. However, the regular use of systemic …

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

SE Wenzel, LB Schwartz, EL Langmack… - American journal of …, 1999 - atsjournals.org
The mechanisms associated with the development of severe, corticosteroid (CS)-dependent
asthma are poorly understood, but likely heterogenous. It was hypothesized that severe …

Bronchoscopic evaluation of severe asthma: persistent inflammation associated with high dose glucocorticoids

SE Wenzel, SJ Szefler, DYM Leung… - American journal of …, 1997 - atsjournals.org
The role of inflammation in the pathogenesis of severe asthma chronically treated with high
doses of glucocorticoids is poorly understood. Despite this, treatment has been aimed at …