User profiles for S.E.M. Howie

Sarah EM Howie

University of Edinburgh
Verified email at ed.ac.uk
Cited by 10252

The role of infection in miscarriage

…, K Cuschieri, G Entrican, SEM Howie… - Human reproduction …, 2016 - academic.oup.com
… Sarah EM Howie , Sarah EM Howie … Chlamydia trachomatis, an obligate intracellular
bacterium, is the most common sexually transmitted bacterial disease worldwide (Howie et al., 2011…

“Dirty little secrets”—endotoxin contamination of recombinant proteins

…, IR Poxton, JLR Forsythe, OJ Garden, SEM Howie - Immunology letters, 2006 - Elsevier
The identification of Toll-like receptors has revolutionised our understanding of innate
immunity. TLR4 transduces the LPS signal and that of a number of structurally and functionally …

Inflammation‐associated remodelling and fibrosis in the lung–a process and an end point

…, PM Fitch, AJ Simpson, SEM Howie - International Journal …, 2007 - Wiley Online Library
Fibrosis by common usage in the pathological and clinical literature is the end result of a
healing process and synonymous with scarring. We would argue that its use to describe a …

[HTML][HTML] Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

WS Cho, R Duffin, SEM Howie, CJ Scotton… - Particle and fibre …, 2011 - Springer
Background Large production volumes of zinc oxide nanoparticles (ZnONP) might be
anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. …

Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing

…, R Duffin, CA Poland, SEM Howie… - Environmental …, 2010 - ehp.niehs.nih.gov
Background Metal oxide nanoparticles (NPs) have been widely used in industry, cosmetics,
and biomedicine. Objectives We examined hazards of several well-characterized high …

A type 2 (Th2‐like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA)

…, EA Ramage, D Lamb, SEM Howie - Clinical & …, 1995 - Wiley Online Library
CFA is an inflammatory condition of the lungs resulting in scarring, pulmonary failure and
death. The etiology of the disease is unknown, but the pathogenesis is believed to involve a …

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

…, MGF Sharp, OJ Garden, J Hughes, SEM Howie… - Nature medicine, 2016 - nature.com
… Briefly, male mice aged 20 ± 1 weeks (mean ± sem, no age difference between experimental
groups) from our transgenic breeding colony (housed in groups in 12-h light cycles with …

[HTML][HTML] Cerebrospinal fluid markers of neuroinflammation in delirium: a role for interleukin-1β in delirium after hip fracture

…, BC van Munster, A de Vries, SEM Howie… - Journal of …, 2014 - Elsevier
Objective Exaggerated central nervous system (CNS) inflammatory responses to peripheral
stressors may be implicated in delirium. This study hypothesised that the IL-1β family is …

Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up‐regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in …

…, C Haslett, JR Lamb, SEM Howie - The Journal of …, 2003 - Wiley Online Library
During pulmonary development, Sonic hedgehog (Shh) and transforming growth factor β1 (TGF‐β1)
signalling both contribute to branching morphogenesis. In interstitial lung disease, …

An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

…, E Kouverianou, CM Rooney, BJ McHugh, SEM Howie… - Cancer research, 2019 - AACR
… Results are represented as mean ± SEM and statistical tests are described in the figure
legends. … Results from E represent the mean ± SEM of two independent experiments of n = 6. …