User profiles for S. Tual-Chalot
Simon Tual-ChalotResearch Associate Verified email at ncl.ac.uk Cited by 2220 |
[HTML][HTML] Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges
Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by a multi-systemic
vascular dysplasia and hemorrhage. The precise factors leading to these vascular …
vascular dysplasia and hemorrhage. The precise factors leading to these vascular …
Noncoding RNAs in age-related cardiovascular diseases
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult
population worldwide and represent a severe economic burden and public health concern. …
population worldwide and represent a severe economic burden and public health concern. …
[HTML][HTML] Endothelial dysfunction and immunothrombosis in sepsis
E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
… Here, we address the question of how senescence is induced in rarely dividing/post‐mitotic
cardiomyocytes and investigate whether clearance of senescent cells attenuates age‐…
cardiomyocytes and investigate whether clearance of senescent cells attenuates age‐…
Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction
…, E Dookun, R Redgrave, S Tual‐Chalot, S Victorelli… - Aging cell, 2019 - Wiley Online Library
… An important limitation of this study is that our experimental strategy was not able to distinguish
which senescent cell types are responsible for this effect, and it is possible that clearance …
which senescent cell types are responsible for this effect, and it is possible that clearance …
[HTML][HTML] Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression
S Tual-Chalot, M Mahmoud, KR Allinson… - PloS one, 2014 - journals.plos.org
Rare inherited cardiovascular diseases are frequently caused by mutations in genes that
are essential for the formation and/or function of the cardiovasculature. Hereditary …
are essential for the formation and/or function of the cardiovasculature. Hereditary …
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
…, R Redgrave, P Palmowski, S Tual‐Chalot… - Aging cell, 2020 - Wiley Online Library
… In this study, we hypothesized that cellular senescence is an outcome of the oxidative burst
occurring during cardiac IRI and is a key contributor to its associated adverse ventricular …
occurring during cardiac IRI and is a key contributor to its associated adverse ventricular …
Microparticles: targets and tools in cardiovascular disease
MC Martinez, S Tual-Chalot, D Leonetti… - Trends in …, 2011 - cell.com
… This review is focused on the mechanisms of MP formation and their effects on target
cells … Calcium increase is also associated with calpain activation, and this is required for …
cells … Calcium increase is also associated with calpain activation, and this is required for …
The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar
Aging-related cellular and molecular processes including low-grade inflammation are major
players in the pathogenesis of cardiovascular disease (CVD) and Alzheimer’s disease (AD). …
players in the pathogenesis of cardiovascular disease (CVD) and Alzheimer’s disease (AD). …
Circulating microparticles from pulmonary hypertensive rats induce endothelial dysfunction
S Tual-Chalot, C Guibert, B Muller… - American journal of …, 2010 - atsjournals.org
Rationale: Pulmonary arterial hypertension (PAH) is a severe disease characterized by an
increase of pulmonary vascular resistance, which is accompanied by functional and structural …
increase of pulmonary vascular resistance, which is accompanied by functional and structural …