Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

…, PJ Wolters, WZ Bradford, K Kossen, SD Seiwert… - Nature …, 2013 - nature.com
We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic
idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up …

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study

…, FJ Martinez, K Kossen, SD Seiwert… - The Lancet respiratory …, 2013 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease that probably
involves several genetic loci. Several rare genetic variants and one common single nucleotide …

Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis

…, KK Brown, JL Talbert, C Markin, K Kossen, SD Seiwert… - Jama, 2013 - jamanetwork.com
… Drs Kossen and Seiwert are employee shareholders of InterMune Inc, which is pursuing
a license to the aforementioned patent, and have filed patents on use of peripheral blood …

Antifibrotic activities of pirfenidone in animal models

…, DW Ruhrmund, L Pan, SD Seiwert… - European …, 2011 - Eur Respiratory Soc
… [52] treated bile duct ligated rats with pirfenidone (200 mg·kg −1 via oral gavage) and
observed a 60% decrease in hepatic fibrosis (area staining with Masson’s trichrome) with …

A comparison of dynamic coronal plane excursion between matched male and female athletes when performing single leg landings

…, GD Myer, RL Smith, RM Vianello, SL Seiwert… - Clinical …, 2006 - Elsevier
… This measurement was used as each subject’s neutral (zero) alignment; subsequent …
Immediately after landing they had to balance on that leg for ≈2 s before placing their contralateral …

Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227)

SD Seiwert, SW Andrews, Y Jiang… - Antimicrobial agents …, 2008 - Am Soc Microbiol
… The PCR was as follows: 15 s at 95C and 1 min at 60C for 40 cycles. … Additionally, the CC
50 s were determined for six primary normal … CC 50 s were determined as described above. …

[HTML][HTML] Direct visualization of uridylate deletion in vitro suggests a mechanism for kinetoplastid RNA editing

SD Seiwert, S Heidmann, K Stuart - Cell, 1996 - cell.com
… product acting as a nucleophile would insert U('s) at the processing site if attack occurred
5′ of the original gRNA terminus or delete U('s) if attack occurred 3′ to the original terminus. …

Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease

…, L Beigelman, L Blatt, SD Seiwert - Journal of medicinal …, 2014 - ACS Publications
… This was attributed to the compound’s poor cell permeability … so that the molecule’s highly
exposed polar surface area is … This modification indeed increased the compound’s replicon …

RNA editing: a mechanism for gRNA-specified uridylate insertion into precursor mRNA

ML Kable, SD Seiwert, S Heidmann, K Stuart - Science, 1996 - science.org
In the mitochondria of trypanosomatid protozoa the precursors of messenger RNAs (pre-mRNAs)
have their coding information remodeled by the site-specific insertion and deletion of …

Mutations in the conserved loop of human U5 snRNA generate use of novel cryptic 5′ splice sites in vivo.

JJ Cortes, EJ Sontheimer, SD Seiwert, JA Steitz - The EMBO journal, 1993 - embopress.org
We have analyzed base pairing interactions between the U5 snRNA and 5′ exon sequences
during pre‐mRNA splicing in a mammalian in vivo system. We constructed synthetic U5 …