Proposal for Standardization of Optimized Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing of Mycobacterium tuberculosis

…, S Rüsch-Gerdes… - Journal of clinical …, 2006 - Am Soc Microbiol
… x i is the frequency of the ith allele at the locus and n is the number … is the total number of
cases in the sample, c is the number of genotypes represented by at least two cases, and n c is

[HTML][HTML] Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population …

…, ML Rossetti, S Rüsch-Gerdes, A Sajduda, S Samper… - BMC microbiology, 2006 - Springer
… The central role of India, and more generally of Asia in tuberculosis evolutionary history is
more and more evident. The S lineage which is highly prevalent in Sicily and Sardinia, could …

WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update

…, MC Raviglione, ML Rich, S Royce, S Rüsch-Gerdes… - 2011 - Eur Respiratory Soc
… of Xpert MTB/RIF is low in patient groups in which rifampicin resistance is rare. Therefore, to
… This is an important consideration given that access to Xpert MTB/RIF is expected to expand …

[HTML][HTML] Origin, Spread and Demography of the Mycobacterium tuberculosis Complex

…, S Rüsch-Gerdes, C Locht, S Brisse… - PLoS …, 2008 - journals.plos.org
… Taken together, the findings presented in this study indicate that the MTBC is composed
of two major lineages and has emerged approximately 40,000 years ago. This estimate is

[HTML][HTML] Worldwide emergence of extensively drug-resistant tuberculosis

…, MF Rodrigues, S Rüsch-Gerdes… - Emerging infectious …, 2007 - ncbi.nlm.nih.gov
… First-line–drug susceptibility testing is performed on all isolates; second-line–drug
susceptibility testing is usually limited to isolates from patients known or suspected to have drug-…

[HTML][HTML] Whole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular …

…, S Jaenicke, S Schuback, S Rüsch-Gerdes… - PLoS …, 2013 - journals.plos.org
… Our findings suggest that WGS is superior to conventional genotyping for Mtb pathogen
tracing and investigating micro-epidemics. WGS provides a measure of Mtb genome evolution …

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

…, S Lecher, E Willery, MGB Blum, S Rüsch-Gerdes… - Nature …, 2015 - nature.com
… The expansion ratio r = N 0 /N 1 (where N 0 is the current effective population size and N 1
is the effective population size before expansion began) ranged from 8 (BL7) to 25 (CC6). For …

Policy guidance on drug-susceptibility testing (DST) of second-line antituberculosis drugs

…, M Rich, J Ridderhof, F Rodrigues, S Rüsch-Gerdes… - 2015 - europepmc.org
This document is intended to provide an interim policy framework for the laboratory component
relevant to programmatic implementation of MDR-TB strategies. A detailed technical …

Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpert MTB/RIF system

D Hillemann, S Rüsch-Gerdes… - Journal of clinical …, 2011 - Am Soc Microbiol
… , although the Xpert real-time technology is less prone to contamination due to the closed …
One limitation of this study is the small sample size for each of the different specimen types. …

Evaluation of the GenoType MTBDRplus Assay for Rifampin and Isoniazid Susceptibility Testing of Mycobacterium tuberculosis Strains and Clinical Specimens

D Hillemann, S Rüsch-Gerdes… - Journal of clinical …, 2007 - Am Soc Microbiol
s at 95C and 120 s at 58C; an additional 20 cycles comprising 25 s at 95C, 40 s at 53C, and
40 s … cycles comprising 30 s at 95C and 120 s at 58C; an additional 35 cycles comprising 25 …