[HTML][HTML] Lebrikizumab treatment in adults with asthma
…, H Scheerens, LC Wu, Z Su, S Mosesova… - … England Journal of …, 2011 - Mass Medical Soc
Background Many patients with asthma have uncontrolled disease despite treatment with
inhaled glucocorticoids. One potential cause of the variability in response to treatment is …
inhaled glucocorticoids. One potential cause of the variability in response to treatment is …
Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study
…, K Rosén, HJ Hsieh, S Mosesova… - American journal of …, 2013 - atsjournals.org
… The value of Fe NO as a predictor of a patient’s likelihood to respond to ICS treatment is
high, and has been described previously (17); however, because responses to corticosteroid …
high, and has been described previously (17); however, because responses to corticosteroid …
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
G Jia, RW Erickson, DF Choy, S Mosesova… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …
We recently described a distinct subtype of asthma defined by the expression of genes …
Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids
M Noonan, P Korenblat, S Mosesova… - Journal of allergy and …, 2013 - Elsevier
Background Asthma is a disease with marked heterogeneity in its clinical course and
response to treatment. IL-13 is central to type 2 inflammation, which contributes to many key …
response to treatment. IL-13 is central to type 2 inflammation, which contributes to many key …
OX 40L blockade and allergen‐induced airway responses in subjects with mild asthma
…, C Kipling, B Dua, S Mosesova… - Clinical & …, 2014 - Wiley Online Library
Background The OX 40/ OX 40L interaction contributes to an optimal T cell response following
allergic stimuli and plays an important role in the maintenance and reactivation of memory …
allergic stimuli and plays an important role in the maintenance and reactivation of memory …
DNL 104, a centrally penetrant RIPK 1 inhibitor, inhibits RIP 1 kinase phosphorylation in a randomized phase I ascending dose study in healthy volunteers
…, WAJ Birkhoff, GR Tonn, S Mosesova… - Clinical …, 2020 - Wiley Online Library
… The 150 μL of 2× Reading Buffer T (MSD) was added to each well, and the plate was read
using a Sector S 600 plate reader (MSD). The plate was washed three times with 1× TRIS-…
using a Sector S 600 plate reader (MSD). The plate was washed three times with 1× TRIS-…
Effects of RG7652, a monoclonal antibody against PCSK9, on LDL-C, LDL-C subfractions, and inflammatory biomarkers in patients at high risk of or with established …
RG7652 (MPSK3169A), a fully human immunoglobulin G1 (IgG1) monoclonal antibody
directed against proprotein convertase subtilisin/kexin type 9 (PCSK9), blocks the interaction …
directed against proprotein convertase subtilisin/kexin type 9 (PCSK9), blocks the interaction …
[HTML][HTML] A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus …
…, J Lordan, AH Mansur, A Menzies-Gow, S Mosesova… - Trials, 2018 - Springer
Background Patients with difficult-to-control asthma consume 50–60% of healthcare costs
attributed to asthma and cost approximately five-times more than patients with mild stable …
attributed to asthma and cost approximately five-times more than patients with mild stable …
Characterization of IL-17AA and IL-17FF in rheumatoid arthritis and multiple sclerosis
C Schofield, SK Fischer, MJ Townsend, S Mosesova… - Bioanalysis, 2016 - Future Science
Aim: IL-17 is thought to play a prominent role in immune disorders. Sensitive and specific IL-17AA
and IL-17FF assays were developed and used to determine levels in serum and …
and IL-17FF assays were developed and used to determine levels in serum and …
Peripheral blood gene expression predicts clinical benefit from anti–IL-13 in asthma
…, MS Bradley, R Maciuca, S Mosesova… - Journal of Allergy and …, 2016 - jacionline.org
This study was partly supported by grants from the Ministry of Science and Technology,
Taiwan (grant no. MOST 102-2314-B-182-053-MY3) and Chang Gung Memorial Hospital (grant …
Taiwan (grant no. MOST 102-2314-B-182-053-MY3) and Chang Gung Memorial Hospital (grant …