Cardiovascular disease is a leading cause of morbidity and mortality in individuals with Down
syndrome. Congenital heart disease is the most common cardiovascular condition in this …

… 590 dynes·s −1 ·cm −5 was correlated with poor longer-term outcome. Our results show a
slightly lower threshold with 416 dynes·s −1 ·cm −5 for all-cause mortality and 425 dynes·s −1 ·…

… We applied a one-tailed Fisher’s exact test with post hoc Bonferroni correction to calculate
… We applied a one-tailed (greater) Fisher’s exact test with Bonferroni post hoc correction for …

Objective To clarify the clinical characteristics and epidemiology of idiopathic pulmonary
arterial hypertension (IPAH) in childhood, a rare condition with a bad prognosis, poorly …

Primary sclerosing cholangitis (PSC) is a disease of unknown cause that effects the biliary
tree and is closely associated with inflammatory bowel disease. We did a retrospective …

Background Rare genetic variants cause pulmonary arterial hypertension, but the contribution
of common genetic variation to disease risk and natural history is poorly characterised. …

Background: Pulmonary arterial hypertension (PAH) is a rare disease with an emerging
genetic basis. Heterozygous mutations in the gene encoding the bone morphogenetic protein …

… Other echocardiographic measures include the myocardial performance (Tei) index 70
and S’ obtained from tissue Doppler imaging of the tricuspid annulus. Markers of adverse …

… Volumetric data were obtained using retrospectively gated cine imaging (n=37) or real-time
imaging (n=63), depending on the patient’s ability to hold his or her breath. During a median …

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