In the last 4 years, 6 phase 3 trials including a total of 27 023 patients with venous
thromboembolism (VTE) compared a direct oral anticoagulant (DOAC) with vitamin K antagonists (…

… The coagulation cascade is regulated by natural anticoagulants, such as tissue factor pathway
inhibitor, the protein C and protein S system, and antithrombin, all of which help to restrict …

In the early 1960s, shortly after the introduction of oral contraceptives, the first case reports
appeared describing venous thrombosis and pulmonary emboli in women using this method …

… Middeldorp reports grants and fees paid to her institution, outside the present work, from
Abbvie, BMS/Pfizer, Aspen, Daiichi Sankyo, Bayer, Boehringer Ingelheim, Sanofi, and Portola. …

Background The use of anticoagulant therapy during pregnancy is challenging because of
the potential for both fetal and maternal complications. This guideline focuses on the …

… associated with a decrease in hemoglobin of at least 2 g per deciliter or a hemoglobin level
of 8 g per deciliter or less if no baseline hemoglobin level was available (or an investigator’s …

Background Andexanet alfa is a modified recombinant inactive form of human factor Xa
developed for reversal of factor Xa inhibitors. Methods We evaluated 352 patients who had acute …

… admit patients to ICU or treat them with non-invasive mechanical ventilation by their knowledge
of the allocated treatment; random variation could have been caused by the pandemic’s …

… The first visit at the clinic should allow time for the clinician to review the patient’s history, to
… investigations, and to link it to the patient’s history. Staff should be aware that many women …

… of protein C, protein S, and antithrombin. Deficiencies were defined as less than 70% of
normal activity for protein C, less than 65% of normal activity for total protein S, and less than 80…