User profiles for S. Ehl
Stephan EhlCenter for Chronic Immunodeficiency, CIBSS Verified email at uniklinik-freiburg.de Cited by 20211 |
Antigen localisation regulates immune responses in a dose‐and time‐dependent fashion: a geographical view of immune reactivity
RM Zinkernagel, S Ehl, P Aichele, S Oehen… - Immunological …, 1997 - Wiley Online Library
This review summarises experimental evidence to illustrate that induction of immune reactivity
depends upon antigen reaching and being available in lymphoid organs in a dose‐ and …
depends upon antigen reaching and being available in lymphoid organs in a dose‐ and …
DOCK8 deficiency: clinical and immunological phenotype and treatment options-a review of 136 patients
Mutations in DOCK8 result in autosomal recessive Hyper-IgE syndrome with combined
immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and …
immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and …
[HTML][HTML] Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis
…, T Vraetz, G Janka, U Stadt, S Ehl - Arthritis research & …, 2012 - Springer
… T, Chiang SC, Marcenaro S, Meazza R, Bondzio I, Walshe D, Janka G, Lehmberg K, Beutel
K, zur Stadt U, Binder N, Arico M, Moretta L, Henter JI, Ehl S: A prospective evaluation of …
K, zur Stadt U, Binder N, Arico M, Moretta L, Henter JI, Ehl S: A prospective evaluation of …
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations
…, M Kanariou, C Speckmann, S Ehl, A Rensing-Ehl… - Nature medicine, 2014 - nature.com
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of
immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family …
immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family …
[HTML][HTML] Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: a large patient cohort study
…, JDM Edgar, HJ Longhurst, S Ehl… - Journal of Allergy and …, 2017 - Elsevier
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described
combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene …
combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene …
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
KR Engelhardt, S McGhee, S Winkler, A Sassi… - Journal of Allergy and …, 2009 - Elsevier
… Sequencing of DOCK8 cDNA in the proband ARH009 revealed skipping of exon 37 (Fig 4,
S). This deletion is predicted to result in an in-frame deletion of 53 amino acids. Although …
S). This deletion is predicted to result in an in-frame deletion of 53 amino acids. Although …
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency
Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation
factor (MyD) 88 deficiencies impair Toll-like receptor (TLR)-and interleukin-1 receptor-…
factor (MyD) 88 deficiencies impair Toll-like receptor (TLR)-and interleukin-1 receptor-…
Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
… Indeed, studies of experimental infection models in knockout mice have indicated that defense
against S. pneumoniae and S. aureus may depend on IL-1R (64, 65), TLR2 (43, 66), and, …
against S. pneumoniae and S. aureus may depend on IL-1R (64, 65), TLR2 (43, 66), and, …
The European Society for Immunodeficiencies (ESID) registry working definitions for the clinical diagnosis of inborn errors of immunity
Patient registries are instrumental for clinical research in rare diseases. They help to
achieve a sufficient sample size for epidemiological and clinical research and to assess the …
achieve a sufficient sample size for epidemiological and clinical research and to assess the …
Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections
…, T Rieger, V Falcone, F Sorgeloos, S Ehl… - Journal of …, 2010 - Am Soc Microbiol
… After addition of 800 μl of PBS containing 0.3% BSA, organs were subjected to two rounds
of mechanical treatment for 15 s each at 6.5 m/s, with 5 min of incubation on ice between the …
of mechanical treatment for 15 s each at 6.5 m/s, with 5 min of incubation on ice between the …