User profiles for S. Chakarov
Svetoslav ChakarovProfessor of Immunology, Shanghai Jiao Tong University Verified email at shsmu.edu.cn Cited by 5642 |
[PDF][PDF] Determinants of resident tissue macrophage identity and function
Resident tissue macrophages (RTMs) have a broad spectrum of immune- and non-immune-related
tissue-supporting activities. The roots of this heterogeneity and versatility are only …
tissue-supporting activities. The roots of this heterogeneity and versatility are only …
Role of adipose tissue macrophages in obesity-related disorders
… Chakarov is funded by Oriental Scholars of Shanghai Universities (2000000934) and
Foreign … Blériot, and S. Chakarov wrote and edited the manuscript and created the figures. All …
Foreign … Blériot, and S. Chakarov wrote and edited the manuscript and created the figures. All …
[PDF][PDF] Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition
…, M Khudoynazarova, J Agudo, N Tung, S Chakarov… - Immunity, 2016 - cell.com
Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant BRAF
or fail to respond to checkpoint blockade. We explored whether modulation of intratumoral …
or fail to respond to checkpoint blockade. We explored whether modulation of intratumoral …
[PDF][PDF] Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species
… To identify the node(s) corresponding to the cDC1s and cDC2s, we defined them ab initio
as XCR1hiCD24hiCD26hiCD11chiMHCIIhi CD11bloCD172aloF4/…
as XCR1hiCD24hiCD26hiCD11chiMHCIIhi CD11bloCD172aloF4/…
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
S Chakarov, HY Lim, L Tan, SY Lim, P See, J Lum… - Science, 2019 - science.org
… P ≤ 0.01, ****P ≤ 0.0001, and ns is not significant using Student’s t test. Scale bars in (A) …
Evan’s blue (50 μg in 50 μl sterile PBS) was injected into the mice (iv) to label the lung …
Evan’s blue (50 μg in 50 μl sterile PBS) was injected into the mice (iv) to label the lung …
Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration
…, R Ee, R Dress, JW Hang, A Balachander, S Chakarov… - Immunity, 2022 - cell.com
… We show that the previously identified disease-associated microglia (DAM) population
detected in murine Alzheimer’s disease models actually comprises two ontogenetically and …
detected in murine Alzheimer’s disease models actually comprises two ontogenetically and …
[PDF][PDF] Onco-fetal reprogramming of endothelial cells drives immunosuppressive macrophages in hepatocellular carcinoma
We employed scRNA sequencing to extensively characterize the cellular landscape of human
liver from development to disease. Analysis of ∼212,000 cells representing human fetal, …
liver from development to disease. Analysis of ∼212,000 cells representing human fetal, …
[PDF][PDF] Microbial exposure during early human development primes fetal immune cells
The human fetal immune system begins to develop early during gestation; however, factors
responsible for fetal immune-priming remain elusive. We explored potential exposure to …
responsible for fetal immune-priming remain elusive. We explored potential exposure to …
[PDF][PDF] Induced-pluripotent-stem-cell-derived primitive macrophages provide a platform for modeling tissue-resident macrophage differentiation and function
… d iMacs derived from an FMF patient’s iPSCs exhibit diseasespecific characteristics … p
< 0.05, **p < 0.01, ****p < 0.0001 (one-way ANOVA followed by Bonferroni’s multiple-comparison …
< 0.05, **p < 0.01, ****p < 0.0001 (one-way ANOVA followed by Bonferroni’s multiple-comparison …
[PDF][PDF] Fate mapping via Ms4a3-expression history traces monocyte-derived cells
… approved by the Institutional Animal Care and Use Committee (IACUC) of Shanghai Jiao
Tong University School of Medicine and were performed in compliance with the University’s …
Tong University School of Medicine and were performed in compliance with the University’s …