Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic
cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (…

… say which cell macrophage progenitor cell type was most relevant for the therapeutic effect
in our models and whether the transplanted cells proliferated or persisted in the recipient’s …

… iPSCs were generated from patient’s CD34 + bone marrow cells obtained by iliac crest
puncture performed in the course of the patient’s routine diagnostic assessment (Figure 2A). …

… Gene set enrichment analysis using the mSigDB’s chemical and genetic perturbations
collection confirmed that iPSCs expressed embryonic stem cell genes that were downregulated in …

Induced pluripotent stem cells (iPSCs) represent an innovative source for the standardized
in vitro generation of macrophages (Mφ). We here describe a robust and efficient protocol to …

Gene transfer of drug resistance (CTX-R) genes can be used to protect the hematopoietic
system from the toxicity of anticancer chemotherapy and this concept recently has been proven …

Regulated transgene expression may reduce transgene-specific and genotoxic risks
associated with gene therapy. To prove this concept, we have investigated the suitability of …

Patient material from rare diseases such as very early-onset inflammatory bowel disease (VEO-IBD)
is often limited. The use of patient-derived induced pluripotent stem cells (iPSCs) for …

Foxp3 + regulatory T (Treg) cells play a pivotal role in maintaining immunological tolerance.
Loss‐of‐function mutations in the Foxp3 gene result in multiorgan inflammation known as …

Endogenous microRNA (miRNA) expression can be exploited for cell type-specific transgene
expression as the addition of miRNA target sequences to transgenic cDNA allows for …