Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants

N Ito, S Fukushima, H Tsuda - CRC Critical reviews in Toxicology, 1985 - Taylor & Francis
V. SUMMARY Carcinogenicity tests showed that addition of the antioxidant BHA to the diet
of F344 rats induced high incidences of papilloma and squamous cell carcinoma of the …

Tree of motility–A proposed history of motility systems in the tree of life

…, Y Fukumori, S Fukushima, S Haruta… - Genes to …, 2020 - Wiley Online Library
… Archaea have a proteinaceous S-layer which likely lacks some of the mechanical strength
of the bacterial peptidoglycan layer. It is speculated, from gene homology, that an Asgard-like …

Cancer prevention by organosulfur compounds from garlic and onion

S Fukushima, N Takada, T Hori… - Journal of Cellular …, 1997 - Wiley Online Library
… in terms of reduced numbers and areas of liver glutathione S-transferase placental (GST-P) …
Moreover, water-soluble OSCs such as S-methylcysteine and cysteine similarly decreased …

Design of environment‐sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change

Y Bae, S Fukushima, A Harada… - Angewandte Chemie, 2003 - Wiley Online Library
The recent development of biomolecular devices that function within the living body has
required the integration of capabilities for sensing in vivo chemical stimuli, generating detectable …

Development of the polymer micelle carrier system for doxorubicin

T Nakanishi, S Fukushima, K Okamoto, M Suzuki… - Journal of Controlled …, 2001 - Elsevier
We show the result of pre-clinical study of NK911, a polymeric micelle carrier system for
doxorubicin (DOX). The NK911 micelle carrier consists of polyethyleneglycol and conjugated …

Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis

N Ito, M Hirose, S Fukushima, H Tsuda, T Shirai… - Food and Chemical …, 1986 - Elsevier
Studies were conducted on the carcinogenic activity of butylated hydroxyanisole (BHA) in
rats and hamsters. To obtain information concerning the mechanism of action of BHA on the …

Carcinogenicity of butylated hydroxyanisole in F344 rats

N Ito, S Fukushima, A Haqlwara… - Journal of the …, 1983 - academic.oup.com
… None of them detected mutagenic activity on Salmonella typhimurium with S-9 from rat
liver (37, 38). Batzinger et al. (39) and Cumming and Walton (41) found that BHA had …

Doxorubicin-loaded poly (ethylene glycol)–poly (β-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance

…, T Okano, Y Sakurai, S Fukushima… - Journal of Controlled …, 2000 - Elsevier
Doxorubicin (DOX) was physically loaded into micelles prepared from poly(ethylene glycol)–poly(β-benzyl-l-aspartate)
block copolymer (PEG–PBLA) by an o/w emulsion method with a …

Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled …

Y Bae, N Nishiyama, S Fukushima… - Bioconjugate …, 2005 - ACS Publications
A novel intracellular pH-sensitive polymeric micelle drug carrier that controls the systemic,
local, and subcellular distributions of pharmacologically active drugs has been developed in …

Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model

…, S Miyagawa, K Miki, A Saito, S Fukushima… - Circulation, 2012 - Am Heart Assoc
Background— Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs)
are a promising source of cells for regenerating myocardium. However, several issues, …