Urban air pollution and respiratory infections

R Brugha, J Grigg - Paediatric respiratory reviews, 2014 - Elsevier
Public awareness of the impact of air quality on health is increasing worldwide. Indoor and
outdoor air pollutants impair children's growing lungs, and increase the risk of respiratory …

Carbon loading in airway macrophages as a biomarker for individual exposure to particulate matter air pollution—A critical review

Y Bai, RE Brugha, L Jacobs, J Grigg, TS Nawrot… - Environment …, 2015 - Elsevier
Exposure to particulate matter (PM) is associated with adverse health effects, including
chronic lung diseases, lung cancer and cardiovascular disease. Personal exposure varies …

6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a …

…, L Grandjean, E Gaynor, R Brugha… - The Lancet Child & …, 2021 - thelancet.com
Background Paediatric inflammatory multisystem syndrome temporally associated with
SARS-CoV-2 (PIMS-TS) is a new, rare, post-infectious complication of SARS-CoV-2 infection in …

Outdoor air pollution and cystic fibrosis

R Brugha, C Edmondson, JC Davies - Paediatric respiratory reviews, 2018 - Elsevier
Outdoor air pollution is increasingly identified as a contributor to respiratory and cardiovascular
disease. Pro-inflammatory particles and gases are inhaled deep into the lungs, and are …

Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function …

MA Mall, R Brugha, S Gartner, J Legg… - American journal of …, 2022 - atsjournals.org
Rationale: The triple-combination regimen elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA)
was shown to be safe and efficacious in children aged 6 through 11 years with cystic fibrosis …

[HTML][HTML] Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial

…, D Price, M Sanak, JW Holloway, R Brugha… - The Lancet …, 2014 - thelancet.com
Background The effectiveness of intermittent montelukast for wheeze in young children is
unclear. We aimed to assess whether intermittent montelukast is better than placebo for …

DNA methylation profiles between airway epithelium and proxy tissues in children

R Brugha, R Lowe, AJ Henderson… - Acta …, 2017 - Wiley Online Library
Aim Epidemiological studies of deoxyribonucleic acid ( DNA ) methylation in airway disease
have largely been conducted using blood or buccal samples. However, given tissue …

Mycobacterium abscessus in cystic fibrosis

R Brugha, H Spencer - Science, 2021 - science.org
Mycobacterium abscessus is a nontuberculous mycobacterium (NTM) that evades the host
immune system by infecting macrophages, key immune cells involved in clearing inhaled …

[HTML][HTML] Favipiravir induces HuNoV viral mutagenesis and infectivity loss with clinical improvement in immunocompromised patients

…, R Mohammed, S Owens, DM Lowe, R Brugha… - Clinical …, 2024 - Elsevier
Chronic human norovirus (HuNoV) infections in immunocompromised patients result in
severe disease, yet approved antivirals are lacking. RNA-dependent RNA polymerase (RdRp) …

Carbon in airway macrophages from children with asthma

RE Brugha, N Mushtaq, T Round, DH Gadhvi, I Dundas… - Thorax, 2014 - thorax.bmj.com
Background Airway macrophage (AM) phagocytosis is impaired in severe asthma.
Prostaglandin (PG) E 2 and D 2 are increased in severe asthma and suppress AM phagocytic …