Urban air pollution and respiratory infections
R Brugha, J Grigg - Paediatric respiratory reviews, 2014 - Elsevier
Public awareness of the impact of air quality on health is increasing worldwide. Indoor and
outdoor air pollutants impair children's growing lungs, and increase the risk of respiratory …
outdoor air pollutants impair children's growing lungs, and increase the risk of respiratory …
Carbon loading in airway macrophages as a biomarker for individual exposure to particulate matter air pollution—A critical review
Exposure to particulate matter (PM) is associated with adverse health effects, including
chronic lung diseases, lung cancer and cardiovascular disease. Personal exposure varies …
chronic lung diseases, lung cancer and cardiovascular disease. Personal exposure varies …
6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a …
…, L Grandjean, E Gaynor, R Brugha… - The Lancet Child & …, 2021 - thelancet.com
Background Paediatric inflammatory multisystem syndrome temporally associated with
SARS-CoV-2 (PIMS-TS) is a new, rare, post-infectious complication of SARS-CoV-2 infection in …
SARS-CoV-2 (PIMS-TS) is a new, rare, post-infectious complication of SARS-CoV-2 infection in …
Outdoor air pollution and cystic fibrosis
R Brugha, C Edmondson, JC Davies - Paediatric respiratory reviews, 2018 - Elsevier
Outdoor air pollution is increasingly identified as a contributor to respiratory and cardiovascular
disease. Pro-inflammatory particles and gases are inhaled deep into the lungs, and are …
disease. Pro-inflammatory particles and gases are inhaled deep into the lungs, and are …
Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function …
Rationale: The triple-combination regimen elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA)
was shown to be safe and efficacious in children aged 6 through 11 years with cystic fibrosis …
was shown to be safe and efficacious in children aged 6 through 11 years with cystic fibrosis …
[HTML][HTML] Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial
…, D Price, M Sanak, JW Holloway, R Brugha… - The Lancet …, 2014 - thelancet.com
Background The effectiveness of intermittent montelukast for wheeze in young children is
unclear. We aimed to assess whether intermittent montelukast is better than placebo for …
unclear. We aimed to assess whether intermittent montelukast is better than placebo for …
DNA methylation profiles between airway epithelium and proxy tissues in children
R Brugha, R Lowe, AJ Henderson… - Acta …, 2017 - Wiley Online Library
Aim Epidemiological studies of deoxyribonucleic acid ( DNA ) methylation in airway disease
have largely been conducted using blood or buccal samples. However, given tissue …
have largely been conducted using blood or buccal samples. However, given tissue …
Mycobacterium abscessus in cystic fibrosis
R Brugha, H Spencer - Science, 2021 - science.org
Mycobacterium abscessus is a nontuberculous mycobacterium (NTM) that evades the host
immune system by infecting macrophages, key immune cells involved in clearing inhaled …
immune system by infecting macrophages, key immune cells involved in clearing inhaled …
[HTML][HTML] Favipiravir induces HuNoV viral mutagenesis and infectivity loss with clinical improvement in immunocompromised patients
…, R Mohammed, S Owens, DM Lowe, R Brugha… - Clinical …, 2024 - Elsevier
Chronic human norovirus (HuNoV) infections in immunocompromised patients result in
severe disease, yet approved antivirals are lacking. RNA-dependent RNA polymerase (RdRp) …
severe disease, yet approved antivirals are lacking. RNA-dependent RNA polymerase (RdRp) …
Carbon in airway macrophages from children with asthma
RE Brugha, N Mushtaq, T Round, DH Gadhvi, I Dundas… - Thorax, 2014 - thorax.bmj.com
Background Airway macrophage (AM) phagocytosis is impaired in severe asthma.
Prostaglandin (PG) E 2 and D 2 are increased in severe asthma and suppress AM phagocytic …
Prostaglandin (PG) E 2 and D 2 are increased in severe asthma and suppress AM phagocytic …