Enough information has been gained from clinical trials to allow the conclusion that human
gene transfer is feasible, can evoke biologic responses that are relevant to human disease, …

We have administered a recombinant adenovirus vector (AdCFTR) containing the normal
human CFTR cDNA to the nasal and bronchial epithelium of four individuals with cystic fibrosis …

Evidence from divergent sources suggests that some forms of interstitial pulmonary disease
are associated with abnormalities of the cellular immune system. To evaluate whether …

The US National Institute of Neurological Disorders and Stroke convened major stakeholders
in June 2012 to discuss how to improve the methodological reporting of animal studies in …

Idiopathic pulmonary fibrosis is a fatal disorder that starts as an alveolitis and progresses to
interstitial fibrosis. Correlative morphologic, physiologic, and biochemical studies in 29 …

The role of bone marrow (BM)-derived precursor cells in tumor angiogenesis is not known.
We demonstrate here that tumor angiogenesis is associated with recruitment of …

Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate
and mobilize to circulation following specific signals. Matrix metalloproteinase-9 (MMP-…

Direct transfer of the normal cystic fibrosis (CF) transmembrane conductance regulator (CFTR)
gene to airway epitheiium was evaluated using a replicationdeficient recombinant …

The respiratory epithelium is a potential site for somatic gene therapy for the common
hereditary disorders α1-antitrypsin (α1AT) deficiency and cystic fibrosis. A replication-deficient …

Using the monoclonal antibodies OKT4 and OKT8, we determined the proportions of helper
and suppressor T cells in patients with sarcoidosis and high-intensity alveolitis, patients with …