Steady-State Pharmacokinetics of Roflumilast and Roflumilast N-Oxide in Patients with Mild and Moderate Liver Cirrhosis

…, G Lahu, E Peterfai, D Knoerzer, R Herzog… - Clinical …, 2007 - Springer
Background Roflumilast and its primary N-oxide metabolite are targeted Phosphodiesterase
4 (PDE4) inhibitors with similar in vivo potency. Roflumilast is being developed for the …

Investigation of a potential food effect on the pharmacokinetics of roflumilast, an oral, once‐daily phosphodiesterase 4 inhibitor, in healthy subjects

…, R Hermann, A Hünnemeyer, R Herzog… - The Journal of …, 2006 - Wiley Online Library
This open, randomized, single‐dose crossover study investigated effects of a high‐fat meal
on the pharmacokinetics of roflumilast and its major active N‐oxide metabolite. Twelve …

Effects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N‐oxide in healthy subjects

N Nassr, A Huennemeyer, R Herzog… - British journal of …, 2009 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Rifampicin is an antibiotic that is used
to treat pulmonary tuberculosis. It induces several cytochrome P450 (CYP) enzymes and …

Effect of single and repeated doses of ketoconazole on the pharmacokinetics of roflumilast and roflumilast N‐oxide

…, O von Richter, R Hermann, R Herzog… - The Journal of …, 2008 - Wiley Online Library
Effects of single and multiple doses of oral ketoconazole on roflumilast and its active metabolite,
roflumilast N‐oxide, were investigated in healthy subjects. In study 1, subjects (n = 26) …

Effect of Fluvoxamine on the Pharmacokinetics of Roflumilast and Roflumilast N-Oxide

…, G Lahu, A Huennemeyer, R Herzog… - Clinical …, 2007 - Springer
Objective To investigate the effects of steady-state dosing of fluvoxamine, an inhibitor of
cytochrome P450 (CYP) 1A2 and CYP2C19, on the pharmacokinetics of roflumilast, an oral, …

Rolf Herzog (14.5. 1919-24.6. 2006)

K Beck - 2007 - JSTOR
Rolf Herzog ist im Alter von 87 Jahren in Freiburg gestorben. Er gehort zu der Generation von
Ethnologen, die das Fach in der Nachkriegszeit entscheidend gepragt haben. In Freiburg …

Sensitive quantification of roflumilast and roflumilast N-oxide in human plasma by LC–MS/MS employing parallel chromatography and electrospray ionisation

NG Knebel, R Herzog, F Reutter, K Zech - Journal of Chromatography B, 2012 - Elsevier
A high throughput bioanalytical method based on semi-automated liquid extraction and
liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed for the …

Pharmacokinetics of teduglutide in subjects with renal impairment

R Nave, A Halabi, R Herzog, P Schaffer… - European journal of …, 2013 - Springer
Purpose Teduglutide is a recombinant analogue of human glucagon-like peptide-2 that has
recently been approved for the treatment of short bowel syndrome in adults. This study was …

Effect of steady‐state enoxacin on single‐dose pharmacokinetics of roflumilast and roflumilast N‐oxide

G Lahu, N Nassr, R Herzog, M Elmlinger… - The Journal of …, 2011 - Wiley Online Library
Roflumilast is an oral phosphodiesterase 4 (PDE4) inhibitor for the treatment of chronic
obstructive pulmonary disease (COPD). It is metabolized by CYP1A2 and CYP3A4 to its primary …

PostgreSQL--the Linux of databases

R Herzog - Linux Journal, 1998 - dl.acm.org
… by Rolf HerzogRolf Herzog was fascinated by computers since his first steps with the
early TRS-80. He came to Linux with kernel version 1.2.3, when searching for an alternative …