Aim: The relative gastrointestinal toxicity of NSAIDs in normal clinical practice is unknown.
The aim of this study was to estimate the risk of upper gastrointestinal bleeding associated …

Introduction: Drug–drug interactions (DDIs) arise in numerous different ways, involving
pharmacokinetic or pharmacodynamic mechanisms. Adverse drug reactions are a possible …

Aims: To determine in a case-control study possible associations between the development
of acute renal failure in preterm newborns and therapeutic interventions, particularly drug …

Aims Cutaneous manifestations are frequently reported in association with drug use. The
aim of this study was to analyse the skin reactions reported to the spontaneous surveillance …

Objective: To analyse and compare the adverse drug reactions (ADRs) associated with the
use of nimesulide with those associated with diclofenac, ketoprofen, and piroxicam, reported …

Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in
resistance to selected pathogens and in the regulation of inflammation 1 , 2 – 3 . The present …

Objectives To analyse an Italian database of spontaneous reporting of suspected adverse
drug reactions in order to compare the safety profile of amoxicillin and amoxicillin/clavulanic …

Aim Drug‐induced liver injury is one of the most serious adverse drug reactions and the most
frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti‐…

Pharmacovigilance started about 170 years ago, although it was not yet named as such at
that time. It is structured activity in the professional health field, with important social and …

Multinuclear platinum compounds have been designed to circumvent the cellular resistance
to conventional platinum-based drugs. In an attempt to examine the cellular basis of the …