[PDF][PDF] Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
…, S Kharbanda, R Chen, WF Forrest, RH Soriano… - Cancer cell, 2006 - cell.com
Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and
discovered to resemble stages in neurogenesis. One tumor class displaying neuronal …
discovered to resemble stages in neurogenesis. One tumor class displaying neuronal …
Epithelial versus Mesenchymal Phenotype Determines In vitro Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients
…, G Cavet, W Zhu, L Fu, TQ Pham, R Soriano… - Clinical Cancer …, 2005 - AACR
Significant improvements in the outcome of non–small cell lung carcinoma (NSCLC) have
been reported in patients treated with the epidermal growth factor receptor (EGFR) inhibitor, …
been reported in patients treated with the epidermal growth factor receptor (EGFR) inhibitor, …
[PDF][PDF] A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
…, WF Forrest, IM Kasman, JM Greve, RH Soriano… - Cancer cell, 2010 - cell.com
The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that
can initiate neurosphere growth and tumor formation; however, instances of CD133 − cells …
can initiate neurosphere growth and tumor formation; however, instances of CD133 − cells …
Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
…, E Tomlinson, M Renz, PM Williams, R Soriano… - …, 2004 - academic.oup.com
Hormonal control of metabolic rate can be important in regulating the imbalance between
energy intake and expenditure that underlies the development of obesity. In mice fed a high-fat …
energy intake and expenditure that underlies the development of obesity. In mice fed a high-fat …
[HTML][HTML] Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
…, BM Ellingson, CW Bowers, RH Soriano… - Journal of clinical …, 2011 - ncbi.nlm.nih.gov
Purpose Mutation in isocitrate dehydrogenase 1 (IDH1) at R132 (IDH1 R132MUT) is frequent
in low-grade diffuse gliomas and, within glioblastoma (GBM), has been proposed as a …
in low-grade diffuse gliomas and, within glioblastoma (GBM), has been proposed as a …
Exon Array Profiling Detects EML4-ALK Fusion in Breast, Colorectal, and Non–Small Cell Lung Cancers
E Lin, L Li, Y Guan, R Soriano, CS Rivers… - Molecular Cancer …, 2009 - AACR
The echinoderm microtubule-associated protein-like 4–anaplastic lymphoma kinase (EML4-ALK)
fusion gene has been identified as an oncogene in a subset of non–small cell lung …
fusion gene has been identified as an oncogene in a subset of non–small cell lung …
ERK inhibition overcomes acquired resistance to MEK inhibitors
…, JM Spoerke, KP Hoeflich, PM Haverty, R Soriano… - Molecular cancer …, 2012 - AACR
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly
via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric …
via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric …
NRROS negatively regulates reactive oxygen species during host defence and autoimmunity
…, I Peng, A Sebrell, P Caplazi, J DeVoss, RH Soriano… - Nature, 2014 - nature.com
Reactive oxygen species (ROS) produced by phagocytes are essential for host defence
against bacterial and fungal infections. Individuals with defective ROS production machinery …
against bacterial and fungal infections. Individuals with defective ROS production machinery …
Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1
…, A Abbas, V Ramirez-Carrozzi, M Zhou, R Soriano… - Nature …, 2013 - nature.com
Type 2 innate lymphoid cells (ILC2 cells) participate in host defense against helminth parasites
and in allergic inflammation. Given their functional relatedness to type 2 helper T cells (T …
and in allergic inflammation. Given their functional relatedness to type 2 helper T cells (T …
A novel anti-CD22 anthracycline-based antibody–drug conjugate (ADC) that overcomes resistance to auristatin-based ADCs
…, MA Go, J Lau, S Spencer, H Raab, R Soriano… - Clinical Cancer …, 2015 - AACR
Purpose: We are interested in identifying mechanisms of resistance to the current generation
of antibody–drug conjugates (ADC) and developing ADCs that can overcome this …
of antibody–drug conjugates (ADC) and developing ADCs that can overcome this …