Rationale: Extensive evidence in animal models supports a role for IL-13 in the pathobiology
of asthma. IMA-638 and IMA-026 are fully humanized IgG 1 antibodies that bind to different …

To narrow the gap in our understanding of potential oxidative properties associated with
Electronic Nicotine Delivery Systems (ENDS) ie e-cigarettes, we employed semi-quantitative …

Mast cells and basophils are metachromatic cells that participate in allergic inflammation.
Allergen challenge to the airways of atopic asthmatic individuals increases levels of …

Background. Exercise is a common stimulus of bronchoconstriction in subjects with asthma,
who also have bronchoconstriction after inhaling the sulfidopeptide leukotriene D 4 (LTD 4 ). …

Allergen Inhalation causes airway Inflammation and an Increase In histamine airway
responsiveness. We haveused cell counts In sputum Induced by hypertonic saline aerosol to …

Rationale: The drug product TPI ASM8 contains two modified phosphorothioate antisense
oligonucleotides designed to inhibit allergic inflammation by down-regulating human CCR3 …

… Killian MB a , Michel Laviolette MD c , Christopher Carlsten MD g , Nikolaos Lazarinis MD
h , Richard M. Watson BSc a , Joanne Milot BSc c , Veronica Swystun PhD d , Miranda Bowen …

Allergen-induced late airway responses are associated with increased numbers of airway
eosinophils and basophils. The purpose of this study was to compare and contrast the effects …

The effect of regular inhaled β -agonist on the treatment of exercise-induced bronchoconstriction
was studied. Eight subjects with exercise-induced bronchoconstriction took 1 week …

Background Phosphodiesterase 4 (PDE4) inhibitors increase intracellular cyclic adenosine
monophosphate (cAMP), leading to regulation of inflammatory cell functions. Roflumilast is a …