We used a computed tomography (CT) scanner program (“density mask”) that highlights
voxels within a given density range to quantitate emphysema by defining areas of abnormally …

We used a CT program “density mask” outlining areas with attenuation values less than —910
HU, to indicate areas of emphysema on a chest CT and to provide an overall percentage …

BACKGROUND Airway wall thickening has been observed in post mortem studies of
patients with asthma. Assessment of airway wall thickening by high resolution computed …

Toevalute the sensitivity of diffusing capacity (OLeo) and pressure-volume (PV) curves in
the detection of emphysema, these tests were compared with pathologlc assessment of …

An abnormal increase in proteolytic enzymes is thought to play a key role in pulmonary
emphysema. Alveolar macrophage proteolytic enzymes include cathepsin L, cathepsin S, matrix …

A multicentre, cross-sectional study was carried out in six centres across Canada to establish
a national standard for pulmonary function tests using healthy, lifetime nonsmokers, with …

Palovarotene is an oral γ-selective retinoid agonist. In animal emphysema models, palovarotene
reduced inflammation, promoted structural repair and functional improvement. REPAIR (…

Pulmonary emphysema is a major cause of mortality and morbidity in chronic obstructive
pulmonary disease (COPD). Cigarette smoking is a major risk factor in the development of …

We conducted a prospective study to evaluate whether lack of an adequate increase in
diffusing capacity for carbon monoxide (Dl CO ) during exercise is associated with a greater …

The aim of this study was to compare the time course of neutrophil and macrophage elastinolytic
potentials in the lungs of rats exposed daily to cigarette smoke inhalation for 1–6 mo in …