Several studies have demonstrated the importance of Rho-kinase in the modulation of smooth
muscle contraction, airway hyperresponsiveness, and inflammation. However, the effects …

Proteinase inhibitors have been associated with anti-inflammatory and antioxidant activities
and may represent a potential therapeutic treatment for emphysema. Our aim was to …

Background. Elastase mediates important oxidative actions during the development of
chronic obstructive pulmonary disease (COPD). However, few resources for the inhibition of …

Background. Proteinases play a key role in emphysema. Bauhinia bauhinioides cruzipain
inhibitor (BbCI) is a serine-cysteine proteinase inhibitor. We evaluated BbCI treatment in …

Background: Mechanisms linking behavioral stress and inflammation are poorly understood,
mainly in distal lung tissue. Objective: We have investigated whether the forced swim stress …

We evaluated if repeated stress modulates mucociliary clearance and inflammatory
responses in airways of guinea pigs (GP) with chronic inflammation. The GP received seven …

Chronic obstructive pulmonary disease (COPD) can lead to chronic and obstructive bronchitis
and emphysema resulting in decreased bronchial lumen size. This study evaluated the …

Background/Aims: Epidemiological studies suggest that stress has an impact on asthmatic
exacerbations. We evaluated if repeated stress, induced by forced swimming, modulates lung …

Rationale: asthma vulnerability. to evaluate the effect of prenatal exposure to acute stressor
on adult rat offspring’s pulmonary Aims: hyperresponsiveness to methacholine. At the end of …

Bauhinia bauhinioides Cruzipain Inhibitor (BbCI) is a proteinase inhibitor that neutralizes
neutrophil elastase and cathepsin G. The present study evaluated the capacity of BbCI in the …