The majority of asthma exacerbations are associated with respiratory virus infections, mostly
rhinoviruses (RVs)[ 1], due to enhanced inflammation in the airways [2]. These occur …

RATIONALE: Rhinoviruses are a major cause of asthma exacerbations. Experimental
Rhinovirus (RV) infection has been used as a model to study mechanisms of RV-16-induced …

: Asthmatic subjects are at higher risk of developing respiratory complications during or
following a respiratory viral infection. We Rationale hypothesise that this is due to the increased …

RATIONALE: Smoking leads to increased susceptibility to viral airway infections. In vitro,
exposure to cigarette smoke extract increases susceptibility to respiratory viral infection. …

The JAK2V617F mutation is associated with distinct myeloproliferative neoplasms, including
polycythemia vera (PV) and essential thrombocythemia (ET), but it remains unclear how it …

New approaches to evidence synthesis, which use human effort and machine automation in
mutually reinforcing ways, can enhance the feasibility and sustainability of living systematic …

Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in
review currency, accuracy, and utility. We are developing a novel approach to systematic …

While it is important for the evidence supporting practice guidelines to be current, that is
often not the case. The advent of living systematic reviews has made the concept of “living …

A living systematic review (LSR) should keep the review current as new research evidence
emerges. Any meta-analyses included in the review will also need updating as new material …

Background Producing high-quality, relevant systematic reviews and keeping them up to
date is challenging. Cochrane is a leading provider of systematic reviews in health. For …