Inhaled particles and lung cancer. Part A: Mechanisms

…, PJA Borm, C Albrecht, RPF Schins - International journal of …, 2004 - Wiley Online Library
Both occupational and environmental exposure to particles is associated with an increased
risk of lung cancer. Particles are thought to impact on genotoxicity as well as on cell …

Cellular responses to nanoparticles: target structures and mechanisms

…, A Von Mikecz, S Grether-Beck, RPF Schins - …, 2007 - Taylor & Francis
Nanotechnology makes use of the special surface properties of extremely small particles. In
this rapidly growing field, many different materials are produced for a multitude of diverse …

Development of in vitro systems for nanotoxicology: methodological considerations

V Stone, H Johnston, RPF Schins - Critical reviews in toxicology, 2009 - Taylor & Francis
Due to the rapid development of a diverse array of nanoparticles, used in a wide variety of
products, there are now many international activities to assess the potential toxicity of these …

Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10)

…, LA Jimenez, PS Gilmour, RPF Schins… - Free Radical Biology …, 2003 - Elsevier
This review focuses on the potential role that oxidative stress plays in the adverse effects of
PM 10 . The central hypothesis is that the ability of PM 10 to cause oxidative stress underlies …

Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents

RPF Schins, JH Lightbody, PJA Borm, T Shi… - Toxicology and applied …, 2004 - Elsevier
There is conflicting evidence in the literature as to the predominant mechanism and also the
compositional element(s) that drives the pulmonary inflammatory response of ambient …

[HTML][HTML] Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

…, M Davoren, J Boertz, RPF Schins… - Particle and fibre …, 2009 - Springer
Titanium dioxide (TiO 2 ), also known as titanium (IV) oxide or anatase, is the naturally
occurring oxide of titanium. It is also one of the most commercially used form. To date, no …

Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of …

…, G Martra, I Fenoglio, PJA Borm, RPF Schins - Toxicology and applied …, 2007 - Elsevier
Inhaled ultrafine particles show considerably stronger pulmonary inflammatory effects when
tested at equal mass dose with their fine counterparts. However, the responsible …

Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge

…, A Elder, NL Mills, P Møller, RPF Schins… - Environmental …, 2017 - ehp.niehs.nih.gov
Background: A rich body of literature exists that has demonstrated adverse human health
effects following exposure to ambient air particulate matter (PM), and there is strong support for …

Mechanisms of genotoxicity of particles and fibers

RPF Schins - Inhalation toxicology, 2002 - Taylor & Francis
RPF SCHINSRPF SCHINS … altered antioxidant capacities in serum and red blood cells
of coal miners (Schins et al., 1995; Schins & Borm, 1999). In line with our observations, Yamano …

Genotoxicity of poorly soluble particles

RPF Schins, AM Knaapen - Inhalation toxicology, 2007 - Taylor & Francis
Poorly soluble particles such as TiO 2 , carbon black, and diesel exhaust particles have
been evaluated for their genotoxity using both in vitro and in vivo assays, since inhalation of …