User profiles for R.D. Machado
Rajiv MachadoLondon, UK Verified email at sgul.ac.uk Cited by 12095 |
[PDF][PDF] Comprehensive molecular characterization of muscle-invasive bladder cancer
…, L Lolla, Y Lotan, FR Lucchesi, Y Ma, RD Machado… - Cell, 2017 - cell.com
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …
Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension
KB Lane, RD Machado, MW Pauciulo, JR Thomson… - Nature …, 2000 - nature.com
Primary pulmonary hypertension (PPH), characterized by obstruction of pre-capillary pulmonary
arteries, leads to sustained elevation of pulmonary arterial pressure (mean> 25 mm Hg …
arteries, leads to sustained elevation of pulmonary arterial pressure (mean> 25 mm Hg …
[HTML][HTML] Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
RC Trembath, JR Thomson, RD Machado… - … England Journal of …, 2001 - Mass Medical Soc
Background Most patients with familial primary pulmonary hypertension have defects in the
gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming …
gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming …
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family
JR Thomson, RD Machado, MW Pauciulo… - Journal of medical …, 2000 - jmg.bmj.com
BACKGROUND Primary pulmonary hypertension (PPH), resulting from occlusion of small
pulmonary arteries, is a devastating condition. Mutations of the bone morphogenetic protein …
pulmonary arteries, is a devastating condition. Mutations of the bone morphogenetic protein …
Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension
…, CM Treacy, NJ Doughty, L Southgate, RD Machado… - Circulation, 2010 - Am Heart Assoc
Background— Inflammation is a feature of pulmonary arterial hypertension (PAH), and
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …
[PDF][PDF] BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension
RD Machado, MW Pauciulo, JR Thomson… - The American Journal of …, 2001 - cell.com
Primary pulmonary hypertension (PPH) is a potentially lethal disorder, because the elevation
of the pulmonary arterial pressure may result in right-heart failure. Histologically, the …
of the pulmonary arterial pressure may result in right-heart failure. Histologically, the …
Mutations of the TGF‐β type II receptor BMPR2 in pulmonary arterial hypertension
RD Machado, MA Aldred, V James… - Human …, 2006 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in
mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder …
mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder …
Genetics and genomics of pulmonary arterial hypertension
RD Machado, O Eickelberg, CG Elliott… - Journal of the American …, 2009 - jacc.org
Pulmonary arterial hypertension (PAH) is a rare disorder that may be hereditable (HPAH),
idiopathic (IPAH), or associated with either drug-toxin exposures or other medical conditions. …
idiopathic (IPAH), or associated with either drug-toxin exposures or other medical conditions. …
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II)
signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH…
signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH…
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia
…, SA Abdalla, J Rowell, RD Machado… - Journal of medical …, 2003 - jmg.bmj.com
… RD Machado1, … International PPH Consortium:, Lane KB, Machado RD, Pauciulo MW,
Thomson JR, Phillips JA, Loyd JE, Nichols WC, Trembath RC. Heterozygous germline mutations …
Thomson JR, Phillips JA, Loyd JE, Nichols WC, Trembath RC. Heterozygous germline mutations …