User profiles for R.D. Machado

Rajiv Machado

London, UK
Verified email at sgul.ac.uk
Cited by 12095

[PDF][PDF] Comprehensive molecular characterization of muscle-invasive bladder cancer

…, L Lolla, Y Lotan, FR Lucchesi, Y Ma, RD Machado… - Cell, 2017 - cell.com
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …

Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension

KB Lane, RD Machado, MW Pauciulo, JR Thomson… - Nature …, 2000 - nature.com
Primary pulmonary hypertension (PPH), characterized by obstruction of pre-capillary pulmonary
arteries, leads to sustained elevation of pulmonary arterial pressure (mean> 25 mm Hg …

[HTML][HTML] Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia

RC Trembath, JR Thomson, RD Machado… - … England Journal of …, 2001 - Mass Medical Soc
Background Most patients with familial primary pulmonary hypertension have defects in the
gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming …

Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family

JR Thomson, RD Machado, MW Pauciulo… - Journal of medical …, 2000 - jmg.bmj.com
BACKGROUND Primary pulmonary hypertension (PPH), resulting from occlusion of small
pulmonary arteries, is a devastating condition. Mutations of the bone morphogenetic protein …

Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension

…, CM Treacy, NJ Doughty, L Southgate, RD Machado… - Circulation, 2010 - Am Heart Assoc
Background— Inflammation is a feature of pulmonary arterial hypertension (PAH), and
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …

[PDF][PDF] BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension

RD Machado, MW Pauciulo, JR Thomson… - The American Journal of …, 2001 - cell.com
Primary pulmonary hypertension (PPH) is a potentially lethal disorder, because the elevation
of the pulmonary arterial pressure may result in right-heart failure. Histologically, the …

Mutations of the TGF‐β type II receptor BMPR2 in pulmonary arterial hypertension

RD Machado, MA Aldred, V James… - Human …, 2006 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in
mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder …

Genetics and genomics of pulmonary arterial hypertension

RD Machado, O Eickelberg, CG Elliott… - Journal of the American …, 2009 - jacc.org
Pulmonary arterial hypertension (PAH) is a rare disorder that may be hereditable (HPAH),
idiopathic (IPAH), or associated with either drug-toxin exposures or other medical conditions. …

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

…, X Yang, M Southwood, S Gräf, RD Machado… - Nature medicine, 2015 - nature.com
Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II)
signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH…

Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

…, SA Abdalla, J Rowell, RD Machado… - Journal of medical …, 2003 - jmg.bmj.com
RD Machado1, … International PPH Consortium:, Lane KB, Machado RD, Pauciulo MW,
Thomson JR, Phillips JA, Loyd JE, Nichols WC, Trembath RC. Heterozygous germline mutations …