Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T‐cell responses

F Geissmann, C Auffray, R Palframan… - Immunology and cell …, 2008 - Wiley Online Library
… A landmark study by Roger Palframan and Ulrich von Andrian has shown that during
inflammation in the skin, large numbers of blood-borne monocytes are directly recruited to lymph …

Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues

RT Palframan, S Jung, G Cheng, W Weninger… - The Journal of …, 2001 - rupress.org
Interstitial fluid is constantly drained into lymph nodes (LNs) via afferent lymph vessels. This
conduit enables monocyte-derived macrophages and dendritic cells to access LNs from …

The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment

ES Baekkevold, T Yamanaka, RT Palframan… - The Journal of …, 2001 - rupress.org
Lymphocyte homing to secondary lymphoid tissue is defined by a multistep sequence of
interactions between lymphocytes and endothelial cells in high endothelial venules (HEVs). …

Development of a quantitative tool for the comparison of the prebiotic effect of dietary oligosaccharides

R Palframan, GR Gibson… - Letters in Applied …, 2003 - academic.oup.com
Aims: To develop a quantitative equation [prebiotic index (PI)] to aid the analysis of prebiotic
fermentation of commercially available and novel prebiotic carbohydrates in vitro, using …

Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow

RT Palframan, PD Collins, TJ Williams… - Blood, The Journal of …, 1998 - ashpublications.org
The CC-chemokine eotaxin is a potent eosinophil chemoattractant that stimulates recruitment
of eosinophils from the blood to sites of allergic inflammation. Mobilization from the bone …

[PDF][PDF] Carbohydrate preferences of Bifidobacterium species isolated from the human gut

RJ Palframan, GR Gibson, RA Rastall - Current issues in intestinal …, 2003 - caister.com
The growth of nine species of Bifidobacterium on media containing glucose, xylose,
xylooligosaccharides (XOS), xylan or fructooligosaccharides (FOS) as the sole carbon source were …

Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo

M Shimaoka, C Lu, RT Palframan… - Proceedings of the …, 2001 - National Acad Sciences
The integrin αLβ2 has three different domains in its headpiece that have been suggested to
either bind ligand or to regulate ligand binding. One of these, the inserted or I domain, has a …

Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo

…, S Marleau, SM Rankin, RT Palframan… - The Journal of …, 1997 - rupress.org
Challenge of the airways of sensitized guinea pigs with aerosolized ovalbumin resulted in
an early phase of microvascular protein leakage and a delayed phase of eosinophil …

In vitro fermentation of sugar beet arabinan and arabino‐oligosaccharides by the human gut microflora

M Al‐Tamimi, RJ Palframan, JM Cooper… - Journal of Applied …, 2006 - academic.oup.com
Aims: To determine the fermentation profiles by human gut bacteria of arabino‐oligosaccharides
of varying degree of polymerization. Materials and Methods: Sugar beet arabinan was …

Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3 …

RT Palframan, PD Collins, NJ Severs… - The Journal of …, 1998 - rupress.org
Mobilization of bone marrow eosinophils is a critical early step in their trafficking to the lung
during allergic inflammatory reactions. We have shown previously that the cytokine …