Alterations of the nitric oxide receptor, soluble guanylate cyclase (sGC) may contribute to
the pathophysiology of pulmonary arterial hypertension (PAH). In the present study, the …

The cells responsible for production of the male sex hormone testosterone, the Leydig cells
of the testis, are post-mitotic cells with neuroendocrine characteristics. Their origin during …

In this review, the role of oxytocin and oxytocin-like agents (acting via the oxytocin receptor
and belonging to the oxytocin-family) in the male reproductive tract is considered. Previous …

… The M r is similar both to the calculated M r and the apparent M r of the heterologously
expressed CNCβ1f (Fig. 3, right, lane βs). The occurrence of two CNCβ1f bands of ∼76 and ∼92 …

… R Middendorff R Middendorff Signaling Group, Institute of Anatomy and Cell Biology, Justus
… that NO also could have an impact on sperm transport (Davidoff & Middendorff 2000). …

cells, and the testicular localization of the intermediate filament protein nestin, known to be
expressed in neural stem cells, by our group was the first step to define mural cells (pericytes …

… An FRT site (gray triangles)–flanked PGK-neo r cassette is located upstream of the second
loxP site. B, Bam HI; X, Xho I. Probes and sizes of genomic DNA fragments as expected by …

Previous studies have demonstrated that nitric oxide (NO) influences Leydig cell function.
Here we provide evidence for NO production and activity in seminiferous tubules and blood …

A number of marker substances for neuronal and neuroendocrine cells have been
demonstrated in the cytoplasm of the interstitial Leydig cells of human testes using basic …

Replacement of aspartate residue 541 by alanine (D541A) in the pore of TRPV6 channels
in mice disrupts Ca 2+ absorption by the epididymal epithelium, resulting in abnormally high …