The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex
and expensive, tests. In many cases, however, the diagnosis remains difficult despite the …

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous inherited disorder arising
from dysmotility of motile cilia and sperm. This is associated with a variety of ultrastructural …

Diseases caused by Streptococcus pneumoniae include pneumonia, septicaemia and
meningitis. All these are associated with high morbidity and mortality. The pneumococcus can …

Primary ciliary dyskinesia most often arises from loss of the dynein motors that power ciliary
beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized …

Reduced generation of multiple motile cilia (RGMC) is a rare mucociliary clearance disorder.
Affected persons suffer from recurrent infections of upper and lower airways because of …

BACKGROUND: Epithelial dysfunction has been implicated in asthma pathophysiology, but
no studies have directly assessed ciliary function in asthma. OBJECTIVE: To study the ciliary …

Motile cilia and flagella beat rhythmically on the surface of cells to power the flow of fluid
and to enable spermatozoa and unicellular eukaryotes to swim. In humans, defective ciliary …

Ciliopathies are caused by mutations in genes encoding proteins required for cilia organization
or function. We show through colocalization with PCM-1, that OFD1 (the product of the …

Rationale: Respiratory syncytial virus (RSV) is a highly contagious pathogen with a huge
global health impact. It is a major cause of hospital-acquired infection; a large number of those …

Rationale: Respiratory syncytial virus (RSV) and Streptococcus pneumoniae are major
respiratory pathogens. Coinfection with RSV and S. pneumoniae is associated with severe and …