Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF

…, K Prikk, T Sorsa, P Maisi, R Sepper… - European …, 2002 - Eur Respiratory Soc
… numbers and collagenase activity (r=0.263, p<0.05) and MMP-8 levels (r=0.276, p<0.05). …
between ELISA and zymographic measurements of the proenzyme (r=0.56, p<0.0001). …

Telemonitoring in chronic obstructive pulmonary disease (CHROMED). A randomized clinical trial

…, G Munaro, D Marušič, R Sepper, R Rosso… - American journal of …, 2018 - atsjournals.org
Rationale: Early detection of chronic obstructive pulmonary disease (COPD) exacerbations
using telemonitoring of physiological variables might reduce the frequency of hospitalization. …

[HTML][HTML] Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma

…, E Pirilä, MA Reintam, T Salo, T Sorsa, R Sepper - Laboratory …, 2002 - Elsevier
Matrix metalloproteinases (MMPs) contribute to extracellular matrix and basement membrane
degradation in asthma. The present study analyzed molecular forms and degree of …

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

…, MC Shepherd, R Sepper… - … of Physiology-Lung …, 2004 - journals.physiology.org
The expression profile of a panel of 15 cAMP phosphodiesterase isoforms was determined
for inflammatory cell types of relevance to chronic obstructive pulmonary disease (COPD). In …

In vivo collagenase‐2 (MMP‐8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis

K Prikk, E Pirilä, R Sepper, P Maisi… - The Journal of …, 2001 - Wiley Online Library
The purpose of this study was to determine whether other cellular sources than neutrophils
can express matrix metalloproteinase (MMP)‐8 protein and mRNA in bronchiectatic (BE) lung…

Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease

R Sepper, YT Konttinen, Y Ding, M Takagi, T Sorsa - Chest, 1995 - Elsevier
… ρ su is the concentration of collagen in the stock of substrate used; V su is the volume of
substrate solution; p is the percent of degradation of native type I collagen substrate; M r is the …

Direct demonstration of tissue uptake of an inhaled drug: proof-of-principle study using matrix-assisted laser desorption ionization mass spectrometry imaging

…, P Ross, M Dahlback, G Edula, R Sepper… - Analytical …, 2011 - ACS Publications
Drug therapy is often directed to specific organ and tissue compartments where the mode of
action of the compound affects specifically targeted biological processes. However, the …

Cross-border teleradiology—experience from two international teleradiology projects

P Ross, R Sepper, H Pohjonen - European journal of radiology, 2010 - Elsevier
… In R-Bay we found that it is necessary to have continuous … In both, Baltic eHealth and R-Bay
we used very limited … In Baltic eHealth and R-Bay we used streaming technology in two …

Proteomics: is it an approach to understand the progression of chronic lung disorders?

R Sepper, K Prikk - Journal of Proteome Research, 2004 - ACS Publications
Tissue injury, mediated by pathologically elevated production and action of various serine-
and matrix metalloproteinases (MMPs), is a hallmark of chronic inflammatory airway diseases …

Soluble membrane‐type 1 matrix metalloproteinase (MT1‐MMP) and gelatinase A (MMP‐2) in induced sputum and bronchoalveolar lavage fluid of human bronchial …

P Maisi, K Prikk, R Sepper, E Pirilä, T Salo, J Hietanen… - Apmis, 2002 - Wiley Online Library
The aim of this study was to investigate the involvement of the MT1‐MMP/MMP‐2 cascade
in induced sputum (IS) and bronchoalveolar lavage fluid (BALF) from bronchial asthma (BA) …