… Naeije has received research grant support from Actelion, Encysive, and Pfizer; and has
served as a consultant and/or steering committee member for Actelion, Encysive, Lung Rx, …

Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV systolic …

Mild-to-moderate pulmonary hypertension is a common complication of chronic obstructive
pulmonary disease (COPD); such a complication is associated with increased risks of …

Background Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of
prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and …

Pulmonary arterial hypertension is a life-threatening disease for which continuous intravenous
prostacyclin has proven to be effective. However, this treatment requires a permanent …

Objectives : We sought to determine the optimal dose of the selective endothelin A (ET A )
receptor antagonist sitaxsentan for the treatment of pulmonary arterial hypertension (PAH); for …

Objectives : The purpose of this study was to examine the efficacy and safety of four doses
of ambrisentan, an oral endothelin type A receptor-selective antagonist, in patients with …

Objectives : The purpose of this study was to assess the efficacy and safety of beraprost
sodium, an orally active prostacyclin analogue, in New York Heart Association (NYHA) …

… and lung function was weak (FEV 1 , r 2 = 0.11 and Pao 2 , r 2 = 0.03). The mPAP was more
closely related to pulmonary capillary wedge pressure (PCWP) (r 2 = 0.32), which was mildly …

… right atrial pressure (RAP).9, 10, 11, 12 Several studies have shown modest to good correlations
between estimated RV systolic pressure and invasively measured pressures (R = 0.57–…