Whereas the role of bronchial smooth muscle remains controversial in healthy subjects its
role is well established in asthmatics. Bronchial smooth muscle contraction induces airway …

The chronic inflammatory response within the airways of asthmatics is associated with structural
changes termed airway remodeling. This remodeling process is a key feature of severe …

… Marthan, “Selected contribution: tryptase-induced PAR-2mediated Ca2+ signaling in human
… Molimard, JP Savineau, and R. Marthan, “Muscarinic stimulation of airway smooth muscle …

Asthma and chronic obstructive pulmonary disease (COPD) are characterized by different
patterns of airway remodeling, which all include an increased mass of bronchial smooth …

This study investigates factors influencing the risk of pneumothorax and chest tube placement
in patients undergoing CT-guided transthoracic lung biopsy for pulmonary lesions using a …

Background: Recent observations in asthma suggest that bronchial smooth muscle is infiltrated
by inflammatory cells including mast cells. Such an infiltration may contribute to airway …

Airway remodeling with smooth muscle cell (SMC) hyperplasia is a feature of chronic asthma.
We investigated the potential for tryptase, the major secretory product of human mast cells, …

1 This study investigates the role of nitric oxide (NO) and reactive oxygen species (ROS) on
endothelial function of pulmonary arteries in a mice model of hypoxia‐induced pulmonary …

… was significantly correlated with the BSM mass in subjects with asthma (Spearman r = 0.37;
P = 0.04) (Figure 6C). Finally, we … The r represents the Spearman correlation coefficient. …

Human airway smooth muscle cells (HASMC) secrete fractalkine (FKN), a chemokine the
concentration of which is increased in asthmatic patients. HASMC also induce mast cell …