Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

SJ Ballantyne, JL Barlow, HE Jolin, P Nath… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: IL-25 (IL-17E), a member of the IL-17 family of immunoregulatory cytokines,
has been implicated in the regulation of type 2 immunity. Its roles in antigen-driven airway …

Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia

AS Williams, SY Leung, P Nath… - Journal of applied …, 2007 - journals.physiology.org
Exposure to air pollutants such as ozone (O 3 ) induces airway hyperresponsiveness (AHR)
and airway inflammation. Toll-like receptors (TLR) are first-line effector molecules in innate …

Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125

P Nath, P Eynott, SY Leung, IM Adcock… - European journal of …, 2005 - Elsevier
Asthma is a chronic inflammatory disease of the airways associated with structural changes
such as increased airway smooth muscle mass, which may contribute to impairment of lung …

Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness

P Nath, SY Leung, A Williams, A Noble… - European journal of …, 2006 - Elsevier
p38 mitogen-activated protein kinase (MAPK) plays an important role in the activation of
inflammatory cells and in the proliferation of airway structural cells. We investigated the role of …

Allergen‐induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N‐terminal kinase

PR Eynott, P Nath, SY Leung, IM Adcock… - British journal of …, 2003 - Wiley Online Library
Chronic cellular inflammation and airway wall remodelling with subepithelial fibrosis and
airway smooth muscle (ASM) cell hyperplasia are features of chronic asthma. Jun N‐terminal …

IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response

…, Y Cao, G Vass, S Kierstein, P Nath… - The Journal of …, 2006 - journals.aai.org
The innate immune molecule surfactant protein-D (SP-D) plays an important regulatory role
in the allergic airway response. In this study, we demonstrate that mice sensitized and …

Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation

…, DA Groneberg, A Noble, M Salmon, P Nath… - … of Pharmacology and …, 2003 - ASPET
Chronic cellular inflammation and airway wall remodeling with subepithelial fibrosis and
airway smooth muscle thickening are features of chronic asthma. We determined the role of …

Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125

AS Williams, R Issa, SY Leung, P Nath… - … of Pharmacology and …, 2007 - ASPET
Ozone has potent oxidizing properties, and exposure to ozone causes airway hyper-responsiveness
(AHR) and lung inflammation. We determined the importance of c-Jun NH 2 …

Effect of an inhibitor of Jun N‐terminal protein kinase, SP600125, in single allergen challenge in sensitized rats

…, L Xu, BL Bennett, A Noble, SY Leung, P Nath… - …, 2004 - Wiley Online Library
Jun N‐terminal kinase (JNK) has been implicated in the pathogenesis of inflammatory diseases
including asthma. We examined the effect of SP600125 (anthra [1,9‐cd] pyrazol‐6 (2H)‐…

Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features

SY Leung, P Eynott, P Nath, KF Chung - Journal of allergy and clinical …, 2005 - Elsevier
BACKGROUND: Several topical corticosteroids are available as anti-inflammatory treatment
for asthma. Their comparative effects on allergic inflammation and airway remodeling are …