User profiles for Prescott Woodruff

Prescott Woodruff

Verified email at ucsf.edu
Cited by 29150

T-helper type 2–driven inflammation defines major subphenotypes of asthma

PG Woodruff, B Modrek, DF Choy, G Jia… - American journal of …, 2009 - atsjournals.org
Rationale: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is considered
the central molecular mechanism underlying asthma, and Th2 cytokines are emerging …

[HTML][HTML] Clinical significance of symptoms in smokers with preserved pulmonary function

PG Woodruff, RG Barr, E Bleecker… - … England Journal of …, 2016 - Mass Medical Soc
Background Currently, the diagnosis of chronic obstructive pulmonary disease (COPD)
requires a ratio of forced expiratory volume in 1 second (FEV 1 ) to forced vital capacity (FVC) of …

Human asthma phenotypes: from the clinic, to cytokines, and back again

NR Bhakta, PG Woodruff - Immunological reviews, 2011 - Wiley Online Library
A large body of experimental evidence supports the hypothesis that T‐helper 2 (Th2) cytokines
orchestrate allergic airway inflammation in animal models. However, human asthma is …

[HTML][HTML] Azithromycin for prevention of exacerbations of COPD

…, SM Scharf, GR Washko, PG Woodruff… - … England Journal of …, 2011 - Mass Medical Soc
Background Acute exacerbations adversely affect patients with chronic obstructive pulmonary
disease (COPD). Macrolide antibiotics benefit patients with a variety of inflammatory …

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

PG Woodruff, HA Boushey… - Proceedings of the …, 2007 - National Acad Sciences
Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and
other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute to …

Muc5b is required for airway defence

…, AS Bordt, MG Bowden, JH Sisson, PG Woodruff… - Nature, 2014 - nature.com
Respiratory surfaces are exposed to billions of particulates and pathogens daily. A protective
mucus barrier traps and eliminates them through mucociliary clearance (MCC) 1 , 2 . …

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

…, Q Hamid, P Bradding, JV Fahy, PG Woodruff… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …

COVID-19–related genes in sputum cells in asthma. Relationship to demographic features and corticosteroids

…, CL Rios, MT Montgomery, PG Woodruff… - American journal of …, 2020 - atsjournals.org
Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (…

Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression

PG Woodruff, GM Dolganov, RE Ferrando… - American journal of …, 2004 - atsjournals.org
Bronchial hyperresponsiveness in mild to moderate asthma may result from airway smooth
muscle cell proliferation or acquisition of a hypercontractile phenotype. Because these cells …

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

…, C Hendrickson, MF Krummel, PG Woodruff… - Science translational …, 2021 - science.org
Neutralizing autoantibodies against type I interferons (IFNs) have been found in some patients
with critical coronavirus disease 2019 (COVID-19), the disease caused by severe acute …