User profiles for Pierre-Regis Burgel

Pierre-Régis Burgel

Université Paris Descartes
Verified email at aphp.fr
Cited by 14571

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

…, D Engelhard, C Thumerelle, PR Burgel… - Journal of Experimental …, 2011 - rupress.org
Chronic mucocutaneous candidiasis disease (CMCD) may be caused by autosomal dominant
(AD) IL-17F deficiency or autosomal recessive (AR) IL-17RA deficiency. Here, using whole…

The future of cystic fibrosis care: a global perspective

…, M Macek, S Madge, JC Davies, PR Burgel… - The Lancet …, 2020 - thelancet.com
The past six decades have seen remarkable improvements in health outcomes for people
with cystic fibrosis, which was once a fatal disease of infants and young children. However, …

An official American Thoracic Society/European Respiratory Society statement: research questions in chronic obstructive pulmonary disease

…, A Anzueto, DH Au, PJ Barnes, PR Burgel… - American journal of …, 2015 - atsjournals.org
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity,
mortality, and resource use worldwide. The goal of this Official American Thoracic Society (…

Clinical COPD phenotypes: a novel approach using principal component and cluster analyses

PR Burgel, JL Paillasseur, D Caillaud… - European …, 2010 - Eur Respiratory Soc
Classification of chronic obstructive pulmonary disease (COPD) is usually based on the
severity of airflow limitation, which may not reflect phenotypic heterogeneity. Here, we sought to …

Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects

PR Burgel, P Nesme-Meyer, P Chanez, D Caillaud… - Chest, 2009 - Elsevier
Background Epidemiologic studies indicate that chronic cough and sputum production are
associated with increased mortality and disease progression in COPD subjects. Our objective …

Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium

PR Burgel, JA Nadel - Thorax, 2004 - thorax.bmj.com
The epithelial cells lining the airways serve protective functions. The “barrier function” of the
epithelium protects the individual from damage by inhaled irritants. The epithelium produces …

Future trends in cystic fibrosis demography in 34 European countries

PR Burgel, G Bellis, HV Olesen… - European …, 2015 - Eur Respiratory Soc
Median survival has increased in people with cystic fibrosis (CF) during the past six decades,
which has led to an increased number of adults with CF. The future impact of changes in …

Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke

…, B Jung, JJ Shim, PR Burgel… - … of Physiology-Lung …, 2001 - journals.physiology.org
Mucus hypersecretion from hyperplastic airway goblet cells is a hallmark of chronic obstructive
pulmonary disease (COPD). Although cigarette smoking is thought to be involved in …

Rapid improvement after starting elexacaftor–tezacaftor–ivacaftor in patients with cystic fibrosis and advanced pulmonary disease

PR Burgel, I Durieu, R Chiron, S Ramel… - American journal of …, 2021 - atsjournals.org
… Correspondence and requests for reprints should be addressed to Pierre-Régis Burgel,
MD, Ph.D., Cochin Hospital, Assistance Publique Hôpitaux de Paris, 27 Rue du Faubourg St. …

IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils

…, IF Ueki, T Dao-Pick, PR Burgel… - … of Physiology-Lung …, 2001 - journals.physiology.org
Mucus hypersecretion contributes to the morbidity and mortality in acute asthma. Both T
helper 2 (Th2) cytokines and epidermal growth factor receptor (EGFR) signaling have been …