Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to
selectively inhibit β-amyloid 1 - 42 (Aβ42) secretion, the most toxic component of the senile …

N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) is a novel low-affinity, noncompetitive
N-methyl-d-aspartate receptor antagonist. The current study compared the antinociceptive …

Ganstigmine is an orally active, geneserine derived, carbamate-based acetylcholinesterase
inhibitor developed for the treatment of Alzheimer's disease. The crystal structure of the …

CHF6001 [(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine
1-oxide] is a novel …

1 Our study was aimed at investigating the duration of the bronchodilator action of the
antimuscarinc drug glycopyrrolate compared to tiotropium and ipratropium. 2 In the guinea‐pig …

Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the
development of nocifensive behaviour as well as secondary mechanical allodynia and …

A strategy to overcome the side effect liabilities of oral phosphodiesterase 4 (PDE4) inhibitors
has been to deliver the drugs by inhalation to improve their therapeutic index. We report …

METHODS The anti-inflammatory potency and duration of action of CHF6001 was evaluated
in models of pulmonary neutrophilia (LPS in rats and cigarette smoke in mice) and in a …

CHF3381 is a novel low-affinity, non-competitive N-methyl-D-aspartate (NMDA) receptor
antagonist. The current study compared the antinociceptive effects of CHF3381 with those of …

Inhibitors of phoshodiesterase (PDE) 4 are potent anti-inflammatory agents in vivo as a result
of significant expression of this PDE isoform in a number of inflammatory and immune cells …