Experimental rhinovirus 16 infection in moderate asthmatics on inhaled corticosteroids
PT Adura, E Reed, J Macintyre… - European …, 2014 - Eur Respiratory Soc
The majority of asthma exacerbations are associated with respiratory virus infections, mostly
rhinoviruses (RVs)[ 1], due to enhanced inflammation in the airways [2]. These occur …
rhinoviruses (RVs)[ 1], due to enhanced inflammation in the airways [2]. These occur …
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055
Eleven-nineteen leukemia (ENL) is an epigenetic reader protein that drives oncogenic
transcriptional programs in acute myeloid leukemia (AML). AML is one of the deadliest …
transcriptional programs in acute myeloid leukemia (AML). AML is one of the deadliest …
[PDF][PDF] Virus-host interactions following experimental rhinovirus infection in airways disease
P Adura - 2013 - eprints.soton.ac.uk
… Dr Peter Adura … I thank my supervisors Profs Ratko Djukanovic and Peter H Howarth for their
support… cell surface antigen presentation leading to cytotoxic T cell lysis of virus infected cells…
support… cell surface antigen presentation leading to cytotoxic T cell lysis of virus infected cells…
Experimental Rhinovirus-16 Challenge In Moderate Asthma
P Adura, E Reed, J Macintyre, J del Rosario… - D13. VIRUS-HOST …, 2010 - atsjournals.org
RATIONALE: Rhinoviruses are a major cause of asthma exacerbations. Experimental
Rhinovirus (RV) infection has been used as a model to study mechanisms of RV-16-induced …
Rhinovirus (RV) infection has been used as a model to study mechanisms of RV-16-induced …
[HTML][HTML] Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA
producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in …
producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in …
Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK
TJ Lupoli, A Fay, C Adura… - Proceedings of the …, 2016 - National Acad Sciences
During host infection, Mycobacterium tuberculosis (Mtb) encounters several types of stress
that impair protein integrity, including reactive oxygen and nitrogen species and …
that impair protein integrity, including reactive oxygen and nitrogen species and …
Discovery of TDI-10229: a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10)
…, A Gorovyy, J Ferreira, T Rossetti… - ACS Medicinal …, 2021 - ACS Publications
Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given
the role of this enzyme in intracellular signaling. We describe successful efforts to design …
the role of this enzyme in intracellular signaling. We describe successful efforts to design …
Reviewing big data's role in the digital economy: USA and Africa focus
RA Adeleye, KF Awonuga, NL Ndubuisi… - World Journal of …, 2024 - wjarr.com
In the dynamic landscape of the digital economy, the integration and utilization of Big Data
have emerged as pivotal factors influencing economic growth and innovation. This paper …
have emerged as pivotal factors influencing economic growth and innovation. This paper …
Captain Cook's South Sea Island Vocabularies
P Geraghty - 1983 - JSTOR
… , Tehoe taata no Ierusalema, i haere tia dura i Ieriho, e ati adura i te nana eia, pau i'hora tona
ahu … na tana ea ra, e ia hio adura iana, faaehahau ? adura na tetahi pae ea adura te haere. …
ahu … na tana ea ra, e ia hio adura iana, faaehahau ? adura na tetahi pae ea adura te haere. …
Design, synthesis, and pharmacological evaluation of second-generation soluble adenylyl cyclase (sAC, ADCY10) inhibitors with slow dissociation rates
M Miller, T Rossetti, J Ferreira, L Ghanem… - Journal of medicinal …, 2022 - ACS Publications
Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling.
Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is …
Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is …