Background The major sites of obstruction in chronic obstructive pulmonary disease (COPD)
are small airways (<2 mm in diameter). We wanted to determine whether there was a …

Background Chronic obstructive pulmonary disease (COPD) is a major public health
problem associated with long-term exposure to toxic gases and particles. We examined the …

Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow
obstruction caused by emphysema or airway narrowing, or both. Low attenuation areas (LAA) …

The purpose of this study was to compare the dimensions of the peripheral airways in fatal
asthma with those from patients with nonfatal asthma, mild COPD, and normal lung function. …

This study examines the hypothesis that the cigarette smoke-induced inflammatory process
is amplified in severe emphysema and explores the association of this response with latent …

Quantitative analysis of computed tomography (CT) has been combined with a stereologically
based histologic analysis of lung structure to assess regional lung inflation and the …

Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide 1 .
We performed a genetic association study in 15,256 cases and 47,936 controls, with …

… Correspondence and requests for reprints should be addressed to Peter D. Paré, MD, James
Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British …

Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …