Plasmids are mobile genetics elements that play an important role in the environmental
adaptation of microorganisms. Although plasmids are usually analyzed in cultured …

Immunotherapy using immune checkpoints inhibitors has become the standard treatment for
first and second line therapy in patients with non-small cell lung cancer (NSCLC). However, …

The polyadenosine tail (poly[A]-tail) is a universal modification of eukaryotic messenger
RNAs (mRNAs) and non-coding RNAs (ncRNAs). In budding yeast, Pap1-synthesized mRNA …

Simple Summary Scientists around the world have long been interested in understanding the
biology of cancer. Numerous studies that have been carried out so far clearly show that the …

The immune system plays a key role in cancer suppression. Immunotherapy is widely used
as a treatment method in patients with various types of cancer. Immune checkpoint blockade …

Currently, there are no sensitive diagnostic tests that could allow early detection of lung
cancer. Among some cancer patients, epigenetic changes in the nature of methylation of …

The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here,
we used extensive global transcriptomic and targeted biochemical analyses to identify …

LINE-1 retrotransposition is tightly restricted by layers of regulatory control, with epigenetic
pathways being the best characterized. Looking at post-transcriptional regulation, we now …

The 3′‐end poly(A) tail is an important and potent feature of most mRNA molecules that
affects mRNA fate and translation efficiency. Polyadenylation is a posttranscriptional process …

Immune checkpoint inhibitors (ICIs) represent one of the most promising therapeutic approaches
in metastatic non-small cell lung cancer (M-NSCLC). Unfortunately, approximately 50–…