Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in
the central nervous system, is the primary pathological feature of acute and chronic …

Background Moderate-to-severe hemophilia B is treated with lifelong, continuous coagulation
factor IX replacement to prevent bleeding. Gene therapy for hemophilia B aims to establish …

… Paul van der Valk … Paul van der Valk … It also takes into account the presence of the BBB,
revealed by Paul Ehrlich's studies in the late 1800s showing that solutes and molecules were …

Magnetic resonance imaging (MRI) monitoring of disease progression in multiple sclerosis
is limited by the lack of correlation of abnormalities seen on T2‐weighted imaging, and …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets multiple
organs and causes severe coagulopathy. Histopathological organ changes might not only …

Background There is great interest in chronic obstructive pulmonary disease (COPD) and
the associated large burden of disease. COPD is characterised by frequent day by day …

Background Self management interventions help patients with chronic obstructive
pulmonary disease (COPD) acquire and practise the skills they need to carry out disease‐specific …

A M r 110,000 protein (p110) is overexpressed in P-glycoprotein-negative multidrug-resistant
tumor cell lines of different histogenetic origins. These cell lines show an ATP-dependent …

Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous
system ( CNS ), is the major cause of cognitive and motor dysfunction. While neuronal …

The human multidrug resistance protein (MRP) is a 190 kd membrane glycoprotein that can
cause resistance of human tumor cells to various anticancer drugs, by extruding these drugs …