Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease
K Boelaert, PR Newby, MJ Simmonds… - The American journal of …, 2010 - Elsevier
BACKGROUND: Common autoimmune disorders tend to coexist in the same subjects and
to cluster in families. METHODS: We performed a cross-sectional multicenter study of 3286 …
to cluster in families. METHODS: We performed a cross-sectional multicenter study of 3286 …
Association of the thyroid stimulating hormone receptor gene ( TSHR ) with Graves' disease
…, JC Barrett, MJ Simmonds, PR Newby… - Human molecular …, 2009 - academic.oup.com
Graves’ disease (GD) is a common autoimmune disease (AID) that shares many of its
susceptibility loci with other AIDs. The thyroid stimulating hormone receptor (TSHR) represents the …
susceptibility loci with other AIDs. The thyroid stimulating hormone receptor (TSHR) represents the …
Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages
AM Wood, C Bassford, D Webster, P Newby, P Rajesh… - Thorax, 2011 - thorax.bmj.com
Background Vitamin D-binding protein (DBP) genetic polymorphisms have been associated
with chronic obstructive pulmonary disease (COPD). DBP has an indirect role in …
with chronic obstructive pulmonary disease (COPD). DBP has an indirect role in …
Simvastatin improves neutrophil function and clinical outcomes in pneumonia. A pilot randomized controlled clinical trial
…, PA Howells, J Hazeldine, P Newby… - American journal of …, 2019 - atsjournals.org
Rationale: Population studies suggest improved sepsis outcomes with statins, but the results
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …
Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis
…, FK Kavvoura, OJ Brand, PR Newby… - The Journal of …, 2014 - academic.oup.com
Context: A number of small data sets have suggested a potential role for skewed X chromosome
activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation …
activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation …
The biological effects of double-dose alpha-1 antitrypsin augmentation therapy. A pilot clinical trial
…, P Geraghty, G Holt, E Mendes, PR Newby… - American journal of …, 2019 - atsjournals.org
Rationale: Augmentation therapy with intravenous AAT (alpha-1 antitrypsin) is the only
specific therapy for individuals with pulmonary disease from AAT deficiency (AATD). The …
specific therapy for individuals with pulmonary disease from AAT deficiency (AATD). The …
The clinical and inflammatory relationships between periodontitis and chronic obstructive pulmonary disease
…, S Parmar, S Hobbins, P Newby… - Journal of clinical …, 2020 - Wiley Online Library
Aim To investigate associations between periodontitis and chronic obstructive pulmonary
disease (COPD) with and without alpha‐1 antitrypsin deficiency (AATD), including neutrophil …
disease (COPD) with and without alpha‐1 antitrypsin deficiency (AATD), including neutrophil …
Frailty is associated with neutrophil dysfunction which is correctable with phosphoinositol-3-kinase inhibitors
…, H Crisford, P Nightingale, P Newby… - The Journals of …, 2020 - academic.oup.com
Neutrophil dysfunction has been described with age, appears exaggerated in infection, with
altered phosphoinositol signaling a potential mechanism. However, functional aging is …
altered phosphoinositol signaling a potential mechanism. However, functional aging is …
Hypoxia increases the potential for neutrophil-mediated endothelial damage in chronic obstructive pulmonary disease
…, B Liu, M Long, Z Tong, PR Newby… - American journal of …, 2022 - atsjournals.org
Rationale: Patients with chronic obstructive pulmonary disease (COPD) experience excess
cardiovascular morbidity and mortality, and exacerbations further increase the risk of such …
cardiovascular morbidity and mortality, and exacerbations further increase the risk of such …
[HTML][HTML] The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency
AM Wood, MJ Simmonds, DL Bayley, PR Newby… - Respiratory …, 2008 - Springer
Background Genetic variation may underlie phenotypic variation in chronic obstructive
pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD). …
pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD). …