BACKGROUND: Common autoimmune disorders tend to coexist in the same subjects and
to cluster in families. METHODS: We performed a cross-sectional multicenter study of 3286 …

Graves’ disease (GD) is a common autoimmune disease (AID) that shares many of its
susceptibility loci with other AIDs. The thyroid stimulating hormone receptor (TSHR) represents the …

Background Vitamin D-binding protein (DBP) genetic polymorphisms have been associated
with chronic obstructive pulmonary disease (COPD). DBP has an indirect role in …

Rationale: Population studies suggest improved sepsis outcomes with statins, but the results
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …

Context: A number of small data sets have suggested a potential role for skewed X chromosome
activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation …

Rationale: Augmentation therapy with intravenous AAT (alpha-1 antitrypsin) is the only
specific therapy for individuals with pulmonary disease from AAT deficiency (AATD). The …

Aim To investigate associations between periodontitis and chronic obstructive pulmonary
disease (COPD) with and without alpha‐1 antitrypsin deficiency (AATD), including neutrophil …

Neutrophil dysfunction has been described with age, appears exaggerated in infection, with
altered phosphoinositol signaling a potential mechanism. However, functional aging is …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) experience excess
cardiovascular morbidity and mortality, and exacerbations further increase the risk of such …

Background Genetic variation may underlie phenotypic variation in chronic obstructive
pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD). …