Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

Background Eosinophilic inflammation, which may be a consequence of interleukin-5 action,
is a characteristic feature of some forms of asthma. However, in three previous clinical trials …

Asthma and chronic obstructive pulmonary disease (COPD, also called chronic airflow limitation
(CAL)) are the most frequent diagnoses in patients with intrathoracic airways ob truction […

In 1979 and 1980, the chemical structures of the material previously known as slow-reacting
substance of anaphylaxis were elucidated as 5(S)- hydroxy- 6(R)-glutathionyl- 7,9-trans-11,…

Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and
annually updated a global strategy for asthma management and prevention that has formed …

… Paul M O'Byrne … RA Pauwels, WW Busse, WC Tan, and PM O'Byrne have acted as a
consultant for several pharmaceutical companies including AstraZeneca and have spoken at …

Asthma control is improved by combining inhaled corticosteroids with long-acting β 2 -agonists.
However, fluctuating asthma control still occurs. We hypothesized that in patients …

The optimal treatment for mild asthma is uncertain. We assessed the effects of adding a long-acting
inhaled beta-agonist, formoterol, to low doses of an inhaled corticosteroid, …

Background Thymic stromal lymphopoietin (TSLP) is an epithelial-cell–derived cytokine that
may be important in initiating allergic inflammation. AMG 157 is a human anti-TSLP …

Several short-term studies have shown that inhaled steroids can reduce airway
hyperresponsiveness in asthma. To evaluate whether prolonged treatment can bring about full …